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A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and epithelial-mesenchymal transition.
DC Field | Value | Language |
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dc.contributor.author | 안의용 | - |
dc.contributor.author | 유정은 | - |
dc.contributor.author | 최진섭 | - |
dc.contributor.author | 김광일 | - |
dc.contributor.author | 나득채 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 석재연 | - |
dc.date.accessioned | 2014-12-19T16:52:34Z | - |
dc.date.available | 2014-12-19T16:52:34Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0270-9139 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90360 | - |
dc.description.abstract | Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major primary liver cancers in adults. The phenotypic overlap between HCC and CC has been shown to comprise a continuous liver cancer spectrum. As a proof of this concept, a recent study demonstrated a genomic subtype of HCC that expressed CC-like gene expression traits, such as CC-like HCC, which revealed the common genomic trait of stem-cell-like properties and aggressive clinical outcomes. Scirrhous HCC (S-HCC), a rare variant of HCC, is characterized by abundant fibrous stroma and has been known to express several liver stem/progenitor cell markers. This suggests that S-HCC may harbor common intermediate traits between HCC and CC, including stem-cell traits, which are similar to those of CC-like HCC. However, the molecular and pathological characteristics of S-HCC have not been fully evaluated. By performing gene-expression profiling and immunohistochemical evaluation, we compared the morphological and molecular features of S-HCC with those of CC and HCC. S-HCC expresses both CC-like and stem-cell-like genomic traits. In addition, we observed the expression of core epithelial-mesenchymal transition (EMT)-related genes, which may contribute to the aggressive behavior of S-HCC. Overexpression of transforming growth factor beta (TGF-β) signaling was also found, implying its regulatory role in the pathobiology of S-HCC. Conclusion: We suggest that the fibrous stromal component in HCC may contribute to the acquisition of CC-like gene-expression traits in HCC. The expression of stem-cell-like traits and TGF-β/EMT molecules may play a pivotal role in the aggressive phenotyping of S-HCC. (HEPATOLOGY 2012;55:1776-1786). | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | HEPATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Bile Duct Neoplasms/genetics* | - |
dc.subject.MESH | Bile Duct Neoplasms/mortality | - |
dc.subject.MESH | Bile Duct Neoplasms/pathology | - |
dc.subject.MESH | Bile Ducts, Intrahepatic* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/mortality | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology* | - |
dc.subject.MESH | Cholangiocarcinoma/genetics* | - |
dc.subject.MESH | Cholangiocarcinoma/mortality | - |
dc.subject.MESH | Cholangiocarcinoma/pathology | - |
dc.subject.MESH | Epithelial-Mesenchymal Transition* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibrosis | - |
dc.subject.MESH | Gene Expression Profiling | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms/mortality | - |
dc.subject.MESH | Liver Neoplasms/pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Transforming Growth Factor beta/physiology | - |
dc.title | A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and epithelial-mesenchymal transition. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Jae Yeon Seok | - |
dc.contributor.googleauthor | Deuk Chae Na | - |
dc.contributor.googleauthor | Hyun Goo Woo | - |
dc.contributor.googleauthor | Massimo Roncalli | - |
dc.contributor.googleauthor | So Mee Kwon | - |
dc.contributor.googleauthor | Jeong Eun Yoo | - |
dc.contributor.googleauthor | Ei Yong Ahn | - |
dc.contributor.googleauthor | Gwang Il Kim | - |
dc.contributor.googleauthor | Jin-Sub Choi | - |
dc.contributor.googleauthor | Young Bae Kim | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.identifier.doi | 22234953 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02504 | - |
dc.contributor.localId | A02253 | - |
dc.contributor.localId | A04199 | - |
dc.contributor.localId | A00316 | - |
dc.contributor.localId | A01231 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A01928 | - |
dc.relation.journalcode | J00985 | - |
dc.identifier.eissn | 1527-3350 | - |
dc.identifier.pmid | 22234953 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/hep.25570/abstract | - |
dc.subject.keyword | Adult | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Aged, 80 and over | - |
dc.subject.keyword | Bile Duct Neoplasms/genetics* | - |
dc.subject.keyword | Bile Duct Neoplasms/mortality | - |
dc.subject.keyword | Bile Duct Neoplasms/pathology | - |
dc.subject.keyword | Bile Ducts, Intrahepatic* | - |
dc.subject.keyword | Carcinoma, Hepatocellular/mortality | - |
dc.subject.keyword | Carcinoma, Hepatocellular/pathology* | - |
dc.subject.keyword | Cholangiocarcinoma/genetics* | - |
dc.subject.keyword | Cholangiocarcinoma/mortality | - |
dc.subject.keyword | Cholangiocarcinoma/pathology | - |
dc.subject.keyword | Epithelial-Mesenchymal Transition* | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Fibrosis | - |
dc.subject.keyword | Gene Expression Profiling | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Liver Neoplasms/mortality | - |
dc.subject.keyword | Liver Neoplasms/pathology* | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Signal Transduction | - |
dc.subject.keyword | Transforming Growth Factor beta/physiology | - |
dc.contributor.alternativeName | Ahn, Ei Yong | - |
dc.contributor.alternativeName | Yoo, Jeong Eun | - |
dc.contributor.alternativeName | Choi, Jin Sub | - |
dc.contributor.alternativeName | Kim, Gwang Il | - |
dc.contributor.alternativeName | Na, Deuk Chae | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Seok, Jae Yeon | - |
dc.contributor.affiliatedAuthor | Yoo, Jeong Eun | - |
dc.contributor.affiliatedAuthor | Ahn, Ei Yong | - |
dc.contributor.affiliatedAuthor | Choi, Jin Sub | - |
dc.contributor.affiliatedAuthor | Kim, Gwang Il | - |
dc.contributor.affiliatedAuthor | Na, Deuk Chae | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Seok, Jae Yeon | - |
dc.citation.volume | 55 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1776 | - |
dc.citation.endPage | 1786 | - |
dc.identifier.bibliographicCitation | HEPATOLOGY, Vol.55(6) : 1776-1786, 2012 | - |
dc.identifier.rimsid | 34164 | - |
dc.type.rims | ART | - |
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