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Significance of molecular markers in survival prediction of oral squamous cell carcinoma.

Authors
 Ki–Yeol Kim ; ShengJin Li ; In–Ho Cha ; Xianglan Zhang ; Jeong–Dan Cha 
Citation
 Head & Neck, Vol.34(7) : 929~936, 2012 
Journal Title
 Head & Neck 
ISSN
 1043-3074 
Issue Date
2012
Abstract
BACKGROUND: An accurate system for predicting the survival of patients with oral squamous cell carcinoma (OSCC) will be useful for deciding appropriate therapies. The prediction accuracy of prediction models can be improved by using molecular biomarkers. We constructed a nomogram for predicting the survival of patients with OSCC using clinical variables and molecular markers. METHODS: Protein 53 (p53), insulin-like growth factor II mRNA-binding protein 3 (IMP3), cyclooxygenase 2 (COX2), and HuR were localized immunohistochemistry in 96 patients with primary OSCC who underwent surgical resection between January 1994 and June 2003 at the Yonsei Dental Hospital in Seoul, Korea. RESULTS: On univariate and multivariate analysis, the expression of IMP3 was significantly associated with the risk of death. P53 was also significantly associated with survival of OSCC in the case of negative IMP3 and the prediction accuracy was improved by including these 2 factors in the prediction model. CONCLUSION: Survival in OSCC can be predicted more accurately by using biomarkers. The constructed nomogram predicted survival after treatment for an individual patient with OSCC, and it can be practically used as a tool to help decide which adjuvant treatment is most appropriate.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90333
DOI
10.1002/hed.21856
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral and Maxillofacial Surgery
1. 연구논문 > 5. Research Institutes > Oral Cancer Research Institute
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1002/hed.21856/abstract
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