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Significance of molecular markers in survival prediction of oral squamous cell carcinoma.

Authors
 Ki–Yeol Kim  ;  ShengJin Li  ;  Jeong–Dan Cha  ;  Xianglan Zhang  ;  In–Ho Cha 
Citation
 Head & Neck, Vol.34(7) : 929-936, 2012 
Journal Title
 Head & Neck 
ISSN
 1043-3074 
Issue Date
2012
MeSH
Biomarkers, Tumor/metabolism* ; Carcinoma, Squamous Cell/metabolism* ; Carcinoma, Squamous Cell/mortality ; Cyclooxygenase 2/metabolism ; ELAV Proteins/metabolism ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Mouth Neoplasms/metabolism* ; Mouth Neoplasms/mortality ; Multivariate Analysis ; Prognosis ; RNA-Binding Proteins/metabolism* ; Republic of Korea ; Retrospective Studies ; Tumor Suppressor Protein p53/metabolism*
Keywords
survival prediction ; significant factors ; molecularmarkers ; oral squamous cell carcinoma
Abstract
BACKGROUND: An accurate system for predicting the survival of patients with oral squamous cell carcinoma (OSCC) will be useful for deciding appropriate therapies. The prediction accuracy of prediction models can be improved by using molecular biomarkers. We constructed a nomogram for predicting the survival of patients with OSCC using clinical variables and molecular markers. METHODS: Protein 53 (p53), insulin-like growth factor II mRNA-binding protein 3 (IMP3), cyclooxygenase 2 (COX2), and HuR were localized immunohistochemistry in 96 patients with primary OSCC who underwent surgical resection between January 1994 and June 2003 at the Yonsei Dental Hospital in Seoul, Korea. RESULTS: On univariate and multivariate analysis, the expression of IMP3 was significantly associated with the risk of death. P53 was also significantly associated with survival of OSCC in the case of negative IMP3 and the prediction accuracy was improved by including these 2 factors in the prediction model. CONCLUSION: Survival in OSCC can be predicted more accurately by using biomarkers. The constructed nomogram predicted survival after treatment for an individual patient with OSCC, and it can be practically used as a tool to help decide which adjuvant treatment is most appropriate.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/hed.21856/abstract
DOI
22128038
Appears in Collections:
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Yeol(김기열) ORCID logo https://orcid.org/0000-0001-5357-1067
Zhang, Xiang Lan(장향란)
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
Cha, Jeong Dan(차정단)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90333
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