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Increased incidence of endoscopic erosive esophagitis in solid organ transplant recipients.

Authors
 In Soo Kim ; Hyuk Lee ; Yong Chan Lee ; Sang Kil Lee ; Sung Kwan Shin ; Jun Chul Park 
Citation
 Gut and Liver, Vol.6(3) : 349~354, 2012 
Journal Title
 Gut and Liver 
ISSN
 1976-2283 
Issue Date
2012
Abstract
BACKGROUND/AIMS: Solid organ transplant recipients frequently report gastrointestinal symptoms, especially heartburn or dyspepsia. However, the prevalence of endoscopic erosive esophagitis (EE) and associated risk factors after transplantation are unknown. The aim of this study was to determine whether there was a high incidence of endoscopic findings of EE in solid organ transplant recipients. METHODS: This retrospective case-control study included 256 of 3,152 solid organ transplant recipients who underwent sequential screening upper endoscopic examinations and an equal number of controls. RESULTS: Forty-four (17.2%) and 16 (6.2%) cases of EE were detected in the solid organ transplant and control groups, respectively (p<0.001). In the multivariate analysis, transplantation was significantly associated with EE (odds ratio [OR], 6.48; 95% confidence interval, 2.74 to 15.35). Factors such as old age (OR, 1.17), the presence of a hiatal hernia (OR, 5.84), an increased duration of immunosuppression (OR, 1.07), and the maintenance administration of mycophenolate mofetil (OR, 4.13) were independently associated with the occurrence of EE in the solid organ transplant recipients. CONCLUSIONS: A significant increase in the incidence of endoscopically detected EE was observed in solid organ transplant recipients. This increased incidence was associated with the type and duration of the immunosuppressive therapy.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90324
DOI
10.5009/gnl.2012.6.3.349
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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