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The Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein, a toll-like receptor 4 agonist, enhances dendritic cell-based cancer vaccine potency.
DC Field | Value | Language |
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dc.contributor.author | 신성재 | - |
dc.date.accessioned | 2014-12-19T16:49:26Z | - |
dc.date.available | 2014-12-19T16:49:26Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90262 | - |
dc.description.abstract | In this study, we showed the direct interaction between Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein (FAP) and toll-like receptor4 (TLR4) via co-localization and binding by using confocal microscopy and co-immunoprecipitation assays. FAP triggered the expression of pro- and antiinflammatory cytokines in a TLR4-dependent manner. In addition, FAP-induced cytokine expression in bone marrow-derived dendritic cells (BMDCs) was modulated in part by glycogen synthase kinase-3 (GSK-3). FAP-induced expression of CD80, CD86, major histocompatibility complex (MHC) class I, and MHC class II in TLR4(+/+) BMDCs was not observed in TLR4(-/-) BMDCs. Furthermore, FAP induced DC-mediated CD8(+) T cell proliferation and cytotoxic T lymphocyte (CTL) activity, and suppressed tumor growth with DC-based tumor vaccination in EG7 thymoma murine model. Taken together, these results indicate that the TLR4 agonist, FAP, a potential immunoadjuvant for DC-based cancer vaccination, improves the DC-based immune response via the TLR4 signaling pathway. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adhesins, Bacterial*/genetics | - |
dc.subject.MESH | Adhesins, Bacterial*/metabolism | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/metabolism | - |
dc.subject.MESH | Cancer Vaccines*/therapeutic use | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Cytokines/metabolism | - |
dc.subject.MESH | Dendritic Cells/cytology* | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Gene Expression Regulation | - |
dc.subject.MESH | Glycogen Synthase Kinase 3/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mycobacterium avium/genetics | - |
dc.subject.MESH | Mycobacterium avium/metabolism | - |
dc.subject.MESH | Paratuberculosis/metabolism | - |
dc.subject.MESH | Protein Binding | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | T-Lymphocytes, Cytotoxic/metabolism | - |
dc.subject.MESH | Thymoma*/genetics | - |
dc.subject.MESH | Thymoma*/metabolism | - |
dc.subject.MESH | Toll-Like Receptor 4*/agonists | - |
dc.subject.MESH | Toll-Like Receptor 4*/genetics | - |
dc.subject.MESH | Toll-Like Receptor 4*/metabolism | - |
dc.title | The Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein, a toll-like receptor 4 agonist, enhances dendritic cell-based cancer vaccine potency. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Kyung Tae Noh | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.contributor.googleauthor | Kwang Hee Son | - |
dc.contributor.googleauthor | In Duk Jung | - |
dc.contributor.googleauthor | Hyun Kyu Kang | - |
dc.contributor.googleauthor | Su Jung Lee | - |
dc.contributor.googleauthor | Eun Kyung Lee | - |
dc.contributor.googleauthor | Yong Kyoo Shin | - |
dc.contributor.googleauthor | Ji Chang You | - |
dc.contributor.googleauthor | Yeong-Min Park | - |
dc.identifier.doi | 22322306 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02114 | - |
dc.relation.journalcode | J00860 | - |
dc.identifier.eissn | 2092-6413 | - |
dc.identifier.pmid | 22322306 | - |
dc.subject.keyword | Adhesins, Bacterial*/genetics | - |
dc.subject.keyword | Adhesins, Bacterial*/metabolism | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | CD8-Positive T-Lymphocytes/metabolism | - |
dc.subject.keyword | Cancer Vaccines*/therapeutic use | - |
dc.subject.keyword | Cell Proliferation | - |
dc.subject.keyword | Cytokines/metabolism | - |
dc.subject.keyword | Dendritic Cells/cytology* | - |
dc.subject.keyword | Disease Models, Animal | - |
dc.subject.keyword | Gene Expression Regulation | - |
dc.subject.keyword | Glycogen Synthase Kinase 3/metabolism | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Mice | - |
dc.subject.keyword | Mice, Inbred C57BL | - |
dc.subject.keyword | Mycobacterium avium/genetics | - |
dc.subject.keyword | Mycobacterium avium/metabolism | - |
dc.subject.keyword | Paratuberculosis/metabolism | - |
dc.subject.keyword | Protein Binding | - |
dc.subject.keyword | Signal Transduction | - |
dc.subject.keyword | T-Lymphocytes, Cytotoxic/metabolism | - |
dc.subject.keyword | Thymoma*/genetics | - |
dc.subject.keyword | Thymoma*/metabolism | - |
dc.subject.keyword | Toll-Like Receptor 4*/agonists | - |
dc.subject.keyword | Toll-Like Receptor 4*/genetics | - |
dc.subject.keyword | Toll-Like Receptor 4*/metabolism | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.citation.volume | 44 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 340 | - |
dc.citation.endPage | 349 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, Vol.44(5) : 340-349, 2012 | - |
dc.identifier.rimsid | 34102 | - |
dc.type.rims | ART | - |
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