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Increased CXCL12 expression in the placentae of women with pre-eclampsia.

Authors
 Han Sung Hwang  ;  Han Sung Kwon  ;  In Sook Sohn  ;  Yong Won Park  ;  Young Han Kim 
Citation
 EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol.160(2) : 137-141, 2012 
Journal Title
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
ISSN
 0301-2115 
Issue Date
2012
MeSH
Academic Medical Centers ; Adult ; Blotting, Western ; Chemokine CXCL12/genetics ; Chemokine CXCL12/metabolism* ; Female ; Humans ; Immunohistochemistry ; Organ Specificity ; Placenta/metabolism* ; Placenta/pathology ; Pre-Eclampsia/metabolism* ; Pre-Eclampsia/pathology ; Pre-Eclampsia/physiopathology ; Pregnancy ; Pregnancy Proteins/genetics ; Pregnancy Proteins/metabolism* ; RNA, Messenger/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Severity of Illness Index ; Trophoblasts/metabolism ; Trophoblasts/pathology ; Up-Regulation*
Keywords
CXCL12 ; Pre-eclampsia ; Placenta
Abstract
OBJECTIVE: To investigate the expression pattern of CXC chemokine ligand-12 (CXCL12) in the placentae of normal and pre-eclamptic women.

STUDY DESIGN: Twenty-five women with severe pre-eclampsia and 30 normotensive women, matched for gestational age, were enrolled in the study. Placental tissue from each woman was collected following delivery by caesarean section. Quantitative reverse transcription polymerase chain reaction, Western blot analysis and immunohistochemical staining were performed for mRNA expression, quantification and tissue localization of CXCL12 in each placenta.

RESULTS: CXCL12 expression was greater in pre-eclamptic placentae compared with normal placentae. CXCL12 was detected in most placental tissue cells by immunohistochemical staining. CXCL12 immunoreactivity was significantly greater in syncytiotrophoblasts of pre-eclamptic placentae compared with normal placentae. However, there was no significant difference in CXCL12 immunoreactivity in other tissues between the two groups.

CONCLUSION: CXCL12 expression is significantly greater in the placentae of pre-eclamptic women compared with normal women. This may represent part of a compensatory mechanism for pre-eclampsia.
Full Text
http://www.sciencedirect.com/science/article/pii/S0301211511005951
DOI
22071114
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Han(김영한) ORCID logo https://orcid.org/0000-0003-0645-6028
Park, Yong Won(박용원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90218
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