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Early neurological outcomes according to CHADS2 score in stroke patients with non-valvular atrial fibrillation.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이동현 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 차명진 | - |
dc.contributor.author | 허지회 | - |
dc.contributor.author | 김영대 | - |
dc.contributor.author | 김진권 | - |
dc.contributor.author | 남정모 | - |
dc.contributor.author | 남효석 | - |
dc.date.accessioned | 2014-12-19T16:47:38Z | - |
dc.date.available | 2014-12-19T16:47:38Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1351-5101 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90205 | - |
dc.description.abstract | BACKGROUND AND PURPOSE: A higher CHADS(2) score or CHA(2)DS(2)-VASc score is associated with an increased risk of ischaemic stroke in patients with non-valvular atrial fibrillation (NVAF). However, there are no data regarding early neurological outcomes after stroke according to the risk levels. METHODS: In this study, a total of 649 stroke patients with NVAF were enrolled and categorized into three groups: low-risk (CHADS(2) score of 0-1), moderate-risk (CHADS(2) score 2-3), or high-risk group (CHADS(2) score ≥4). CHA(2)DS(2)-VASc score was divided into four groups including 0-1, 2-3, 4-5, and ≥6. We investigated whether there were differences in initial stroke severity, early neurological outcome, and infarct size according to CHADS(2) score or CHA(2)DS(2)-VASc score in stroke patients with NVAF. RESULTS: The initial National Institutes of Health Stroke Scale (NIHSS) score was highest in high-risk group [9.5, interquartile range (IQR) 4-18], followed by moderate-risk (8, IQR 2-17) and low-risk group (6, IQR 2-15) (P=0.012). Likewise, initial stroke severity increased in a positive fashion with increasing the CHA(2)DS(2)-VASc score. During hospitalization, those in the high-risk group or higher CHA(2)DS(2)-VASc score had less improvement in their NIHSS score. Furthermore, early neurological deterioration (END) developed more frequently as CHADS(2) score or CHA(2)DS(2)-VASc score increased. Multivariate analysis showed being in the high-risk group was independently associated with END (OR 2.129, 95% CI 1.013-4.477). CONCLUSIONS: Our data indicate that patients with NVAF and higher CHADS(2) score or CHA(2)DS(2)-VASc score are more likely to develop severe stroke and a worse clinical course is expected in these patients after stroke presentation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 284~290 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Atrial Fibrillation/complications | - |
dc.subject.MESH | Atrial Fibrillation/physiopathology* | - |
dc.subject.MESH | Brain Ischemia/complications | - |
dc.subject.MESH | Brain Ischemia/physiopathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Registries | - |
dc.subject.MESH | Risk | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Stroke/complications | - |
dc.subject.MESH | Stroke/physiopathology* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Early neurological outcomes according to CHADS2 score in stroke patients with non-valvular atrial fibrillation. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine (예방의학) | - |
dc.contributor.googleauthor | H. J. Hong | - |
dc.contributor.googleauthor | Y. D. Kim | - |
dc.contributor.googleauthor | M.-J. Cha | - |
dc.contributor.googleauthor | J. Kim | - |
dc.contributor.googleauthor | D. H. Lee | - |
dc.contributor.googleauthor | H. S. Lee | - |
dc.contributor.googleauthor | C. M. Nam | - |
dc.contributor.googleauthor | H. S. Nam | - |
dc.contributor.googleauthor | J. H. Heo | - |
dc.identifier.doi | 21914056 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03993 | - |
dc.contributor.localId | A04369 | - |
dc.contributor.localId | A00702 | - |
dc.contributor.localId | A01012 | - |
dc.contributor.localId | A01264 | - |
dc.contributor.localId | A01273 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A02738 | - |
dc.relation.journalcode | J00830 | - |
dc.identifier.eissn | 1468-1331 | - |
dc.identifier.pmid | 21914056 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1468-1331.2011.03518.x/abstract | - |
dc.subject.keyword | atrial fibrillation | - |
dc.subject.keyword | CHADS2 score | - |
dc.subject.keyword | outcome | - |
dc.subject.keyword | stroke | - |
dc.contributor.alternativeName | Lee, Dong Hyun | - |
dc.contributor.alternativeName | Lee, Hye Sun | - |
dc.contributor.alternativeName | Cha, Myoung Jin | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.alternativeName | Kim, Young Dae | - |
dc.contributor.alternativeName | Kim, Jin Kwon | - |
dc.contributor.alternativeName | Nam, Jung Mo | - |
dc.contributor.alternativeName | Nam, Hyo Suk | - |
dc.contributor.affiliatedAuthor | Cha, Myoung Jin | - |
dc.contributor.affiliatedAuthor | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Kim, Young Dae | - |
dc.contributor.affiliatedAuthor | Kim, Jin Kwon | - |
dc.contributor.affiliatedAuthor | Nam, Jung Mo | - |
dc.contributor.affiliatedAuthor | Nam, Hyo Suk | - |
dc.contributor.affiliatedAuthor | Lee, Hye Sun | - |
dc.contributor.affiliatedAuthor | Lee, Dong Hyun | - |
dc.citation.volume | 19 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 284 | - |
dc.citation.endPage | 290 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF NEUROLOGY, Vol.19(2) : 284-290, 2012 | - |
dc.identifier.rimsid | 32424 | - |
dc.type.rims | ART | - |
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