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Low circulating adiponectin levels are associated with insulin resistance in non-obese peritoneal dialysis patients

Authors
 Dong Eun Yoo  ;  Mi Jung Lee  ;  Hyung Jung Oh  ;  Seung Jun Kim  ;  Dong Ho Shin  ;  Tae-Hyun Yoo  ;  Shin-Wook Kang  ;  Kyu Hun Choi  ;  Dae Suk Han  ;  Seung Hyeok Han 
Citation
 ENDOCRINE JOURNAL, Vol.59(8) : 685-695, 2012 
Journal Title
ENDOCRINE JOURNAL
ISSN
 0918-8959 
Issue Date
2012
MeSH
Adiponectin/blood* ; Adult ; Aged ; Body Mass Index ; C-Reactive Protein/metabolism ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; Female ; Homeostasis ; Humans ; Insulin Resistance* ; Interleukin-6/blood ; Kidney Failure, Chronic/blood ; Leptin/blood ; Male ; Middle Aged ; Models, Biological ; Peritoneal Dialysis ; Resistin/blood
Keywords
Insulin resistance ; Non-obese ; Peritoneal dialysis ; Adipokine ; Chronic inflammation
Abstract
In patients with end-stage renal disease (ESRD), circulating adipokine levels are increased due to decreased renal clearance, irrespective of obesity. However, whether adipokines play a role in the development of insulin resistance (IR) in non-obese ESRD patients is unknown. We conducted a cross-sectional study to identify factors associated with IR in 62 non-obese patients on peritoneal dialysis (PD). Non-obesity was defined as body mass index (BMI) <25 kg/m(2). IR was determined using homeostatic model assessment-IR (HOMA-IR). We also measured serum concentrations of adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hsCRP), and IL-6. The average BMI of the study patients was 21.6 kg/m(2). When patients were divided into two groups according to the median value of HOMA-IR, serum adiponectin levels were significantly lower in patients with HOMA-IR > 1.85 than in those with HOMA-IR ≤1.85, whereas serum concentrations of leptin and resistin did not differ between the two groups. In addition, log-transformed HOMA-IR was negatively correlated with adiponectin (γ = -0.464, P < 0.001) and log-transformed high-density lipoprotein cholesterol (γ = -0.250, P = 0.050) and positively correlated with age (γ = 0.334, P = 0.008) and triglyceride (γ = 0.392, P = 0.002). However, resistin, log-transformed leptin and log-transformed hsCRP were not associated with HOMA-IR. In a multiple linear regression model, adiponectin was independently associated with HOMA-IR (β = -0.023, P = 0.015). In conclusion, this study suggests that low circulating adiponectin levels might be involved in IR even in non-obese patients undergoing PD.
Files in This Item:
T201202845.pdf Download
DOI
10.1507/endocrj.ej12-0032
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Kim, Seung Jun(김승준)
Oh, Hyung Jung(오형중)
Yoo, Dong Eun(유동은)
Yoo, Tae Hyun(유태현) ORCID logo https://orcid.org/0000-0002-9183-4507
Lee, Mi Jung(이미정)
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
Han, Dae Suk(한대석)
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90161
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