Cited 64 times in
Resveratrol prevents streptozotocin-induced diabetes by inhibiting the apoptosis of pancreatic β-cell and the cleavage of poly (ADP-ribose) polymerase
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이현정 | - |
dc.contributor.author | 구철룡 | - |
dc.contributor.author | 김숙경 | - |
dc.contributor.author | 이은영 | - |
dc.contributor.author | 이은직 | - |
dc.date.accessioned | 2014-12-19T16:46:13Z | - |
dc.date.available | 2014-12-19T16:46:13Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0918-8959 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90160 | - |
dc.description.abstract | Resveratrol (3,5,4'-trihydroxystilbene; RSV) is one kind of polyphenolic phytoalexin that has many effects on metabolic diseases. This study aimed to evaluate the protective effect of RSV pretreatment on β-cell. Male Sprague Dawley rats weighing 200-230 g were divided into 4 groups: (1) RSV; (2) streptozotocin (STZ, 70 mg/kg, intraperitoneally); (3) STZ after 7 days pretreatment with RSV; and (4) STZ pretreated with nicotinamide. Fasting glucose concentration was measured and an intraperitoneal glucose tolerance test was performed 72 h after STZ injection to determine the diabetic condition. The pancreas was removed 3, 6, 36, and 48 h after STZ injection. STZ induced diabetes in all rats not given RSV pretreatment, whereas none of the RSV-pretreated rats developed diabetes. Pretreatment with RSV inhibited apoptosis and reduced the activation of caspase-3 and poly(ADP-ribose) polymerase (PARP). However, expression of the total length PARP was not affected by pretreatment. Our findings suggest that RSV protects β-cells from STZ simultaneously with inhibiting the activation of PARP. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | ENDOCRINE JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antioxidants/therapeutic use* | - |
dc.subject.MESH | Apoptosis/drug effects* | - |
dc.subject.MESH | Blood Glucose/analysis | - |
dc.subject.MESH | Caspase 3/metabolism | - |
dc.subject.MESH | Diabetes Mellitus, Type 1/blood | - |
dc.subject.MESH | Diabetes Mellitus, Type 1/metabolism | - |
dc.subject.MESH | Diabetes Mellitus, Type 1/pathology | - |
dc.subject.MESH | Diabetes Mellitus, Type 1/prevention & control* | - |
dc.subject.MESH | Enzyme Activation/drug effects* | - |
dc.subject.MESH | Glucose Tolerance Test | - |
dc.subject.MESH | Hyperglycemia/prevention & control | - |
dc.subject.MESH | Hypoglycemic Agents/therapeutic use | - |
dc.subject.MESH | In Situ Nick-End Labeling | - |
dc.subject.MESH | Insulin-Secreting Cells/drug effects* | - |
dc.subject.MESH | Insulin-Secreting Cells/metabolism | - |
dc.subject.MESH | Insulin-Secreting Cells/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Poly (ADP-Ribose) Polymerase-1 | - |
dc.subject.MESH | Poly(ADP-ribose) Polymerases/metabolism* | - |
dc.subject.MESH | Proteolysis/drug effects | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Stilbenes/therapeutic use* | - |
dc.subject.MESH | Streptozocin | - |
dc.subject.MESH | Time Factors | - |
dc.title | Resveratrol prevents streptozotocin-induced diabetes by inhibiting the apoptosis of pancreatic β-cell and the cleavage of poly (ADP-ribose) polymerase | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Cheol Ryong Ku | - |
dc.contributor.googleauthor | Hyeon Jeong Lee | - |
dc.contributor.googleauthor | Suk Kyoung Kim | - |
dc.contributor.googleauthor | Eun Young Lee | - |
dc.contributor.googleauthor | Mi-Kyung Lee | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.identifier.doi | 10.1507/endocrj.ej11-0194 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00201 | - |
dc.contributor.localId | A00646 | - |
dc.contributor.localId | A03050 | - |
dc.contributor.localId | A03042 | - |
dc.contributor.localId | A03296 | - |
dc.relation.journalcode | J00769 | - |
dc.identifier.eissn | 1348-4540 | - |
dc.identifier.pmid | 22068111 | - |
dc.subject.keyword | Resveratrol | - |
dc.subject.keyword | Pancreatic β-cell | - |
dc.subject.keyword | Poly(ADP-ribose) polymerase | - |
dc.subject.keyword | Streptozotocin | - |
dc.contributor.alternativeName | Lee, Hyun Jung | - |
dc.contributor.alternativeName | Ku, Cheol Ryong | - |
dc.contributor.alternativeName | Kim, Sook Kyoung | - |
dc.contributor.alternativeName | Lee, Eun Young | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Ku, Cheol Ryong | - |
dc.contributor.affiliatedAuthor | Kim, Sook Kyoung | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Lee, Eun Young | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Jung | - |
dc.citation.volume | 59 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 103 | - |
dc.citation.endPage | 109 | - |
dc.identifier.bibliographicCitation | ENDOCRINE JOURNAL, Vol.59(2) : 103-109, 2012 | - |
dc.identifier.rimsid | 32397 | - |
dc.type.rims | ART | - |
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