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Efficacy of leukotriene receptor antagonist for erosive esophagitis: a preliminary retrospective comparative study.

 H. Lee  ;  J. C. Park  ;  S. K. Shin  ;  S. K. Lee  ;  Y. C. Lee 
 DISEASES OF THE ESOPHAGUS, Vol.25(7) : 595-599, 2012 
Journal Title
Issue Date
Acetates/therapeutic use* ; Adult ; Asthma/complications ; Asthma/drug therapy ; Body Mass Index ; Case-Control Studies ; Esophagitis, Peptic/complications ; Esophagitis, Peptic/drug therapy* ; Esophagoscopy ; Female ; Gastroesophageal Reflux/complications ; Gastroesophageal Reflux/drug therapy* ; Hernia, Hiatal/complications ; Humans ; Leukotriene Antagonists/therapeutic use* ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Quinolines/therapeutic use* ; Retrospective Studies ; Risk Factors
endoscopy ; esophagitis ; gastroesophageal reflux ; leukotriene antagonists
While diagnostic overlap exists between gastroesophageal reflux disease and eosinophilic esophagitis especially on histological findings, therapeutic approaches for the two disease entities are very different. Recently, anti-inflammatory treatment, in addition to acid suppressants, has been investigated for gastroesophageal reflux disease. This study investigated whether the incidence of endoscopic erosive esophagitis was lower in recipients of long-term leukotriene receptor antagonist (LTRA) treatment. This retrospective comparative study included 207 recipients of an LTRA and an equal number of controls who underwent screening upper endoscopic examination. Twenty-two (10.6%) and 51 (24.6%) cases of erosive esophagitis were detected in the LTRA and control groups, respectively (P < 0.001). A significantly higher incidence of minimal change esophagitis was also found in the controls compared with the LTRA group (14.5% vs. 2.4%, P < 0.001). On multivariate analysis, LTRA treatment was significantly and inversely associated with erosive esophagitis (odds ratio [OR], 0.25; 95% confidence interval [CI], 0.13 to 0.46). Within the LTRA treatment group, an increased risk of erosive esophagitis was strongly associated with the presence of hiatal hernia (OR, 5.89; 95% CI, 2.20-15.73, P < 0.001) and short duration of LTRA treatment (OR, 0.64; 95% CI, 0.37-0.89, P= 0.022). In conclusion, this preliminary retrospective analysis demonstrated that patients who underwent long-term treatment with a LTRA had low incidence of endoscopic minimal change esophagitis.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jun Chul(박준철) ORCID logo https://orcid.org/0000-0001-8018-0010
Shin, Sung Kwan(신성관) ORCID logo https://orcid.org/0000-0001-5466-1400
Lee, Sang Kil(이상길) ORCID logo https://orcid.org/0000-0002-0721-0364
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Lee, Hyuk(이혁)
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