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Association of the Brain-derived Neurotrophic Factor Gene and Clinical Features of Bipolar Disorder in Korea.

Authors
 Hye Ji Min  ;  Hyun-Sang Cho  ;  Se Joo Kim  ;  Jeong-Ho Seok  ;  Eun Lee  ;  Duk-In Jon 
Citation
 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, Vol.10(3) : 163-167, 2012 
Journal Title
 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE 
ISSN
 1738-1088 
Issue Date
2012
Keywords
Age of onset ; Bipolar disorder ; Brain-derived neurotrophic factor ; Polymorphism
Abstract
OBJECTIVE: Brain-derived neurotrophic factor (BDNF) plays an important role in cell survival, differentiation, and cell death as well as in neural plasticity. Recent studies have suggested that BDNF is involved in the pathogenesis of bipolar disorder. The aim of this study was to investigate the association of the genetic variations of the BDNF gene with bipolar disorder in Korea. We also studied the possible association of these genetic variants with clinical features. METHODS: The allelic and genotypic distributions of Val66Met polymorphism of the BDNF gene were analyzed using a polymerase chain reaction-based method in 184 bipolar patients and 214 controls. Analysis was performed to investigate an association of the Val66Met polymorphism of the BDNF gene and the clinical features in bipolar patients. RESULTS: No significant difference was found between bipolar patients and controls in the genotype and allele frequencies for the investigated BDNF polymorphism. However, the age of onset of bipolar disorder among the Val/Val (25.57), Val/Met (30.42) and Met/Met (32.45) genotype groups were significantly different (p=0.037). CONCLUSION: This study suggests that Val66Met polymorphisms are unlikely to contribution to the genetic predisposition to bipolar disorder as a whole. But Val66Met polymorphism may be associated with age of onset of the disorder, further studies designed to investigate the relationship in a larger population may be warranted.
Files in This Item:
T201205182.pdf Download
DOI
23430274
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Seok, Jeong Ho(석정호) ORCID logo https://orcid.org/0000-0002-9402-7591
Lee, Eun(이은) ORCID logo https://orcid.org/0000-0002-7462-0144
Cho, Hyun Sang(조현상) ORCID logo https://orcid.org/0000-0003-1019-9941
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90043
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