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Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Korean children and adolescents.

 Sei Eun Hyun  ;  Byung Churl Lee  ;  Byung Kyu Suh  ;  So Chung Chung  ;  Cheol Woo Ko  ;  Heung Sik Kim  ;  Kee Hyoung Lee  ;  Sei Won Yang  ;  Choong Ho Shin  ;  Jin Soon Hwang  ;  Duk Hee Kim  ;  Baek Keun Lim  ;  Jong Duck Kim  ;  Han-Wook Yook  ;  Hye Soon Kim  ;  Woo Yeong Chung  ;  Mi Jung Park  ;  Young Jong Woo  ;  Chan Jong Kim  ;  Dae-Yeol Lee  ;  Eun Young Kim  ;  Jin Ho Choi  ;  Heon Seok Han  ;  Il Tae Hwang  ;  Ho-Seong Kim 
 CLINICAL BIOCHEMISTRY, Vol.45(1-2) : 16-21, 2012 
Journal Title
Issue Date
Adolescent ; Child ; Child, Preschool ; Female ; Growth Disorders/blood ; Humans ; Immunoradiometric Assay/methods ; Infant ; Infant, Newborn ; Insulin-Like Growth Factor Binding Protein 3/blood* ; Insulin-Like Growth Factor I/biosynthesis* ; Korea ; Male ; Reference Values
IGF-I ; IGFBP-3 ; Korean ; Child ; Adolescent
OBJECTIVE: Measurements of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) are utilized in the diagnostic work-up and clinical management of children with growth disorders. We designed this study to establish the reference values of serum IGF-I and IGFBP-3 levels according to age, sex and pubertal stage in Korean children and adolescents.

METHODS: For the study, 1378 healthy Korean children and adolescents aged 0 to 17 years (722 boys, 656 girls) were randomly selected. Blood samples were collected, and the stored sera were assayed for IGF-I and IGFBP-3 using immunoradiometric assay (IRMA, Immunotech). The R 2.8.1 program (Bell Laboratories) was used to generate reference percentile curves for IGF-I and IGFBP-3 according to age, sex, and pubertal stage

RESULTS: Serum IGFBP-3 level was higher in girls compared to that in boys of the same ages throughout the pubertal period, whereas IGF-I was only higher for girls younger than 13 years of age. Serum levels of IGF-I and IGFBP-3 increased steadily with age in the prepubertal stage, followed by a progressive decline thereafter. Peak levels of serum IGF-I and IGFBP-3 were observed two years earlier in girls compared to those in boys (13 vs. 15 years of age, respectively). Serum IGF-I and IGFBP-3 concentrations were highest at Tanner stage IV in boys and girls, with a subsequent decline.

CONCLUSIONS: Our reference value model based on age, sex, and pubertal stage can improve the diagnostic utility of IGF-1 and IGFBP-3 levels in the evaluation and management of Korean children and adolescents with growth disorders.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Duk Hee(김덕희)
Kim, Ho Seong(김호성) ORCID logo https://orcid.org/0000-0003-1135-099X
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