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Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Korean children and adolescents.

 Sei Eun Hyun ; Byung Churl Lee ; Jin Soon Hwang ; Choong Ho Shin ; Ho-Seong Kim ; Il Tae Hwang ; Heon Seok Han ; Jin Ho Choi ; Eun Young Kim ; Dae-Yeol Lee ; Chan Jong Kim ; Young Jong Woo ; Mi Jung Park ; Woo Yeong Chung ; Hye Soon Kim ; Han-Wook Yook ; Jong Duck Kim ; Baek Keun Lim ; Duk Hee Kim ; Sei Won Yang ; Kee Hyoung Lee ; Heung Sik Kim ; Cheol Woo Ko ; So Chung Chung ; Byung Kyu Suh 
 Clinical Biochemistry, Vol.45(1-2) : 16~21, 2012 
Journal Title
 Clinical Biochemistry 
Issue Date
OBJECTIVE: Measurements of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) are utilized in the diagnostic work-up and clinical management of children with growth disorders. We designed this study to establish the reference values of serum IGF-I and IGFBP-3 levels according to age, sex and pubertal stage in Korean children and adolescents. METHODS: For the study, 1378 healthy Korean children and adolescents aged 0 to 17 years (722 boys, 656 girls) were randomly selected. Blood samples were collected, and the stored sera were assayed for IGF-I and IGFBP-3 using immunoradiometric assay (IRMA, Immunotech). The R 2.8.1 program (Bell Laboratories) was used to generate reference percentile curves for IGF-I and IGFBP-3 according to age, sex, and pubertal stage RESULTS: Serum IGFBP-3 level was higher in girls compared to that in boys of the same ages throughout the pubertal period, whereas IGF-I was only higher for girls younger than 13 years of age. Serum levels of IGF-I and IGFBP-3 increased steadily with age in the prepubertal stage, followed by a progressive decline thereafter. Peak levels of serum IGF-I and IGFBP-3 were observed two years earlier in girls compared to those in boys (13 vs. 15 years of age, respectively). Serum IGF-I and IGFBP-3 concentrations were highest at Tanner stage IV in boys and girls, with a subsequent decline. CONCLUSIONS: Our reference value model based on age, sex, and pubertal stage can improve the diagnostic utility of IGF-1 and IGFBP-3 levels in the evaluation and management of Korean children and adolescents with growth disorders.
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