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Learning from HSV-infected mice as a model of Behçet's disease.

Authors
 S. Sohn  ;  E. Lee  ;  D. Bang 
Citation
 Clinical and Experimental Rheumatology, Vol.30(3 Suppl 72) : 96-103, 2012 
Journal Title
 Clinical and Experimental Rheumatology 
ISSN
 0392-856X 
Issue Date
2012
MeSH
Animals ; Antiviral Agents/pharmacology ; Behcet Syndrome/drug therapy ; Behcet Syndrome/genetics ; Behcet Syndrome/immunology ; Behcet Syndrome/pathology ; Behcet Syndrome/virology* ; Disease Models, Animal ; Disease Progression ; Herpes Simplex/drug therapy ; Herpes Simplex/genetics ; Herpes Simplex/immunology ; Herpes Simplex/pathology ; Herpes Simplex/virology* ; Herpesvirus 1, Human/drug effects ; Herpesvirus 1, Human/immunology ; Herpesvirus 1, Human/pathogenicity* ; Humans ; Immunosuppressive Agents/pharmacology ; Mice ; Risk Factors
Keywords
Behçet’s disease ; animal model ; herpes simplex virus ; application
Abstract
Several animal models of Behçet's disease (BD) have been proposed according to putative etiology. Among these models, the herpes simplex virus (HSV)-induced model produced the most similar disease attributes observe in patients. Inoculation of HSV type 1 to the scratched earlobe of mice produced the appropriate symptoms, including oral, genital, and skin ulcers, eye lesions, arthritis, and intestinal involvement. This HSV-induced BD model is the only continuously used model, to which various therapeutic modalities have been applied.
Full Text
http://www.clinexprheumatol.org/abstract.asp?a=5448
DOI
22766172
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Bang, Dong Sik(방동식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90002
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