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Efficacy of clotinab in acute myocardial infarction trial-ST elevation myocardial infarction (ECLAT-STEMI).

Authors
 Jung-Sun Kim ; Sang-Min Park ; Yangsoo Jang ; Junghan Yoon ; Myung-Ho Jeong ; Chong Jin Kim ; Seong-Wook Park ; Seung-Jae Tahk ; Bum Kee Hong ; Hyeon-Cheol Gwon ; Byung Ok Kim ; In Whan Seong ; Myeong-Ki Hong ; Donghoon Choi ; Young-Guk Ko ; Byeong-Keuk Kim 
Citation
 Circulation Journal, Vol.76(2) : 405~413, 2012 
Journal Title
 Circulation Journal 
ISSN
 1346-9843 
Issue Date
2012
Abstract
BACKGROUND: This study investigated the efficacy and the safety of the upstream glycoprotein (Gp) IIb/IIIa inhibitor (clotinab; ISU ABXIS, Seoul, Republic of Korea) under 600-mg clopidogrel pretreatment compared with provisional use in ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS: A total of 786 STEMI patients were randomized to upstream use in the emergency room (ER) (n = 392) or provisional use during percutaneous coronary intervention (PCI) (n = 394). All patients were prescribed 600-mg clopidogrel in the ER. The primary endpoint was the 30-day incidence of composite events including death, nonfatal myocardial infarction, target vessel revascularization, and stroke. There was no significant difference in the events that occurred in 40 patients (10.2%) in the upstream arm and 55 patients (14.0%) in the provisional arm during the 30 days (odds ratio 0.70, 95% confidence interval 0.45-1.08). Major bleeding was higher in the upstream arm (1.5% vs. 0%, P = 0.02). However, there was a significant reduction in 30-day composite events in the upstream arm in the high-risk population (Killip class ≥II or GRACE score >140). CONCLUSIONS: The upstream use of clotinab under a 600-mg clopidogrel loading may not significantly reduce cardiac events following primary PCI but may improve the clinical outcome in high-risk patients.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/89956
DOI
10.1253/circj.CJ-11-0676
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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