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Tumor-infiltrating regulatory T cells delineated by upregulation of PD-1 and inhibitory receptors.

DC Field Value Language
dc.contributor.author김원우-
dc.contributor.author성진실-
dc.contributor.author이은정-
dc.contributor.author이익재-
dc.contributor.author조병철-
dc.date.accessioned2014-12-19T16:38:39Z-
dc.date.available2014-12-19T16:38:39Z-
dc.date.issued2012-
dc.identifier.issn0008-8749-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89918-
dc.description.abstractFoxp3(+) regulatory T (T(reg)) cells are dominant suppressor cells which regulate conventional T (T(conv)) cells. Inside tumor microenvironment, T(reg) cells have been known to become potent in suppressing T(conv) cell responses, thereby enabling tumor cells to circumvent immune response. However, the underlying mechanism by which tumor-infiltrating T(reg) cells display enhanced suppressive function is still unresolved. To understand characteristics and function of tumor-infiltrating T(reg) cells as well as T(conv) cells in the tumor site, we analyzed their phenotypes either within tumor burden or at distant site of tumor using both heterotopic and orthotopic mouse cancer models. Compared to CD8(+) T cells at distant site of tumor, tumor-infiltrating CD8(+) T cells dramatically upregulated programmed death 1 (PD-1) and other inhibitory receptors, thereby being more exhausted functionally. Tumor-infiltrating CD4(+) T cells also expressed higher level of PD-1 than CD4(+) T cells at distant site of tumor but very surprisingly, upregulation of PD-1 occurred in CD4(+)Foxp3(+) T(reg) as well as CD4(+)Foxp3(-) T(conv) cells. Moreover, tumor infiltrating T(reg) cells upregulated other inhibitory receptors such as T cell immunoglobulin mucin 3 (TIM-3), cytotoxic T lymphocyte antigen-4 (CTLA-4), glucocorticoid-induced tumor necrosis factor receptor (GITR), and lymphocyte activation gene-3 (LAG-3). These results suggest that upregulation of PD-1 and other inhibitory receptors on tumor-infiltrating T(reg) cells is related with their enhanced suppressive function.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCELLULAR IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleTumor-infiltrating regulatory T cells delineated by upregulation of PD-1 and inhibitory receptors.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorHyo Jin Park-
dc.contributor.googleauthorAnthony Kusnadi-
dc.contributor.googleauthorEun-Jung Lee-
dc.contributor.googleauthorWon Woo Kim-
dc.contributor.googleauthorByoung Chul Cho-
dc.contributor.googleauthorIk Jae Lee-
dc.contributor.googleauthorJinsil Seong-
dc.contributor.googleauthorSang-Jun Ha-
dc.identifier.doi10.1016/j.cellimm.2012.07.001-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00768-
dc.contributor.localIdA01956-
dc.contributor.localIdA03055-
dc.contributor.localIdA03822-
dc.contributor.localIdA03047-
dc.relation.journalcodeJ00498-
dc.identifier.eissn1090-2163-
dc.identifier.pmidTILs ; Tumor-infiltrating Treg cells ; PD-1 ; Inhibitory receptors-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0008874912001384-
dc.subject.keywordTILs-
dc.subject.keywordTumor-infiltrating Treg cells-
dc.subject.keywordPD-1-
dc.subject.keywordInhibitory receptors-
dc.contributor.alternativeNameKim, Won Woo-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.alternativeNameLee, Eun Jung-
dc.contributor.alternativeNameLee, Ik Jae-
dc.contributor.alternativeNameCho, Byoung Chul-
dc.contributor.affiliatedAuthorKim, Won Woo-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.contributor.affiliatedAuthorLee, Ik Jae-
dc.contributor.affiliatedAuthorCho, Byoung Chul-
dc.contributor.affiliatedAuthorLee, Eun Jung-
dc.citation.volume278-
dc.citation.number1-2-
dc.citation.startPage76-
dc.citation.endPage83-
dc.identifier.bibliographicCitationCELLULAR IMMUNOLOGY, Vol.278(1-2) : 76-83, 2012-
dc.identifier.rimsid31978-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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