Cited 0 times in
Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신성재 | - |
dc.date.accessioned | 2014-12-19T16:38:18Z | - |
dc.date.available | 2014-12-19T16:38:18Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1931-3128 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89906 | - |
dc.description.abstract | The current standard of treatment against tuberculosis consists of a cocktail of first-line drugs, including isoniazid and pyrazinamide. Although these drugs are known to be bactericidal, contribution of host cell responses in the context of antimycobacterial chemotherapy, if any, remains unknown. We demonstrate that isoniazid and pyrazinamide promote autophagy activation and phagosomal maturation in Mycobacterium tuberculosis (Mtb)-infected host cells. Treatment of Mtb-infected macrophages with isoniazid or pyrazinamide caused significant activation of cellular and mitochondrial reactive oxygen species and autophagy, which was triggered by bacterial hydroxyl radical generation. Mycobacterium marinum-infected autophagy-defective, atg7 mutant Drosophila exhibited decreased survival rates, which could not be rescued by antimycobacterial treatment, indicating that autophagy is required for effective antimycobacterial drug action in vivo. Moreover, activation of autophagy by antibiotic treatment dampened Mtb-induced proinflammatory responses in macrophages. Together, these findings underscore the importance of host autophagy in orchestrating successful antimicrobial responses to mycobacteria during chemotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CELL HOST & MICROBE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antitubercular Agents/pharmacology* | - |
dc.subject.MESH | Autophagy/immunology* | - |
dc.subject.MESH | Autophagy-Related Protein 7 | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Drosophila | - |
dc.subject.MESH | Drosophila Proteins/deficiency | - |
dc.subject.MESH | Drosophila Proteins/immunology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Isoniazid/pharmacology | - |
dc.subject.MESH | Macrophages/drug effects | - |
dc.subject.MESH | Macrophages/immunology | - |
dc.subject.MESH | Macrophages/microbiology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mycobacterium marinum/drug effects | - |
dc.subject.MESH | Mycobacterium marinum/immunology* | - |
dc.subject.MESH | Mycobacterium marinum/pathogenicity | - |
dc.subject.MESH | Mycobacterium tuberculosis/drug effects | - |
dc.subject.MESH | Mycobacterium tuberculosis/immunology* | - |
dc.subject.MESH | Mycobacterium tuberculosis/pathogenicity | - |
dc.subject.MESH | Phagosomes/drug effects | - |
dc.subject.MESH | Phagosomes/metabolism | - |
dc.subject.MESH | Pyrazinamide/pharmacology | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism | - |
dc.subject.MESH | Survival Analysis | - |
dc.title | Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Jwa-Jin Kim | - |
dc.contributor.googleauthor | Hye-Mi Lee | - |
dc.contributor.googleauthor | Dong-Min Shin | - |
dc.contributor.googleauthor | Wonho Kim | - |
dc.contributor.googleauthor | Jae-Min Yuk | - |
dc.contributor.googleauthor | Hyo Sun Jin | - |
dc.contributor.googleauthor | Sang-Hee Lee | - |
dc.contributor.googleauthor | Guang-Ho Cha | - |
dc.contributor.googleauthor | Jin-Man Kim | - |
dc.contributor.googleauthor | Zee-Won Lee | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.contributor.googleauthor | Heekyung Yoo | - |
dc.contributor.googleauthor | Young Kil Park | - |
dc.contributor.googleauthor | Jin Bong Park | - |
dc.contributor.googleauthor | JongKyeong Chung | - |
dc.contributor.googleauthor | Tamotsu Yoshimori | - |
dc.contributor.googleauthor | Eun-Kyeong Jo | - |
dc.identifier.doi | 22607799 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02114 | - |
dc.relation.journalcode | J00484 | - |
dc.identifier.eissn | 1934-6069 | - |
dc.identifier.pmid | 22607799 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1931312812001266 | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Antitubercular Agents/pharmacology* | - |
dc.subject.keyword | Autophagy/immunology* | - |
dc.subject.keyword | Autophagy-Related Protein 7 | - |
dc.subject.keyword | Cells, Cultured | - |
dc.subject.keyword | Drosophila | - |
dc.subject.keyword | Drosophila Proteins/deficiency | - |
dc.subject.keyword | Drosophila Proteins/immunology | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Isoniazid/pharmacology | - |
dc.subject.keyword | Macrophages/drug effects | - |
dc.subject.keyword | Macrophages/immunology | - |
dc.subject.keyword | Macrophages/microbiology | - |
dc.subject.keyword | Mice | - |
dc.subject.keyword | Mycobacterium marinum/drug effects | - |
dc.subject.keyword | Mycobacterium marinum/immunology* | - |
dc.subject.keyword | Mycobacterium marinum/pathogenicity | - |
dc.subject.keyword | Mycobacterium tuberculosis/drug effects | - |
dc.subject.keyword | Mycobacterium tuberculosis/immunology* | - |
dc.subject.keyword | Mycobacterium tuberculosis/pathogenicity | - |
dc.subject.keyword | Phagosomes/drug effects | - |
dc.subject.keyword | Phagosomes/metabolism | - |
dc.subject.keyword | Pyrazinamide/pharmacology | - |
dc.subject.keyword | Reactive Oxygen Species/metabolism | - |
dc.subject.keyword | Survival Analysis | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.citation.volume | 11 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 457 | - |
dc.citation.endPage | 468 | - |
dc.identifier.bibliographicCitation | CELL HOST & MICROBE, Vol.11(5) : 457-468, 2012 | - |
dc.identifier.rimsid | 31974 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.