233 265

Cited 19 times in

Potential association between coronary artery disease and the inflammatory biomarker YKL-40 in asymptomatic patients with type 2 diabetes mellitus.

DC FieldValueLanguage
dc.contributor.author강은석-
dc.contributor.author김원진-
dc.contributor.author김현민-
dc.contributor.author송영미-
dc.contributor.author이병완-
dc.contributor.author이현철-
dc.contributor.author장혁재-
dc.contributor.author차봉수-
dc.contributor.author최동훈-
dc.contributor.author유희태-
dc.date.accessioned2014-12-19T16:37:47Z-
dc.date.available2014-12-19T16:37:47Z-
dc.date.issued2012-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89890-
dc.description.abstractBACKGROUND: Inflammation plays an important role in coronary artery disease from the initiation of endothelial dysfunction to plaque formation to final rupture of the plaque. In this study, we investigated the potential pathophysiological and clinical relevance of novel cytokines secreted from various cells including adipocytes, endothelial cells, and inflammatory cells, in predicting coronary artery disease (CAD) in asymptomatic subjects with type 2 diabetes mellitus. METHODS: We enrolled a total of 70 asymptomatic type 2 diabetic patients without a documented history of cardiovascular disease, and determined serum levels of chemerin, omentin-1, YKL-40, and sCD26. We performed coronary computed tomographic angiography (cCTA) in all subjects, and defined coronary artery stenosis ≥ 50 % as significant CAD in this study. RESULTS: Subjects were classified into two groups: patients with suspected coronary artery stenosis on cCTA (group I, n = 41) and patients without any evidence of stenosis on cCTA (group II, n = 29). Group I showed significantly higher YLK-40 levels and lower HDL-C levels than group II (p = 0.038, 0.036, respectively). Levels of chemerin, omentin-1, and sCD26 were not significantly different between the two groups. Serum YKL-40 levels were positively correlated with systolic/diastolic BP, fasting/postprandial triglyceride levels, and Framingham risk score. Furthermore, YKL-40 levels showed moderate correlation with the degree of coronary artery stenosis and the coronary artery calcium score determined from cCTA. In multivariate logistic analysis, after adjusting for age, gender, smoking history, hypertension, and LDL-cholesterol, YLK-40 levels showed only borderline significance. CONCLUSIONS: YKL-40, which is secreted primarily from inflammatory cells, was associated with several CVD risk factors and was elevated in type 2 diabetic patients with suspected coronary artery stensosis on cCTA. These results suggest the possibility that the inflammatory biomarker YKL-40 might be associated with coronary artery disease in asymptomatic patients with type 2 diabetes mellitus.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfCARDIOVASCULAR DIABETOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePotential association between coronary artery disease and the inflammatory biomarker YKL-40 in asymptomatic patients with type 2 diabetes mellitus.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHyun Min Kim-
dc.contributor.googleauthorByung-Wan Lee-
dc.contributor.googleauthorYoung-Mi Song-
dc.contributor.googleauthorWon Jin Kim-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.contributor.googleauthorDong-Hoon Choi-
dc.contributor.googleauthorHee Tae Yu-
dc.contributor.googleauthorEunSeok Kang-
dc.contributor.googleauthorBong Soo Cha-
dc.contributor.googleauthorHyun Chul Lee-
dc.identifier.doi10.1186/1475-2840-11-84-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00068-
dc.contributor.localIdA00772-
dc.contributor.localIdA01110-
dc.contributor.localIdA02039-
dc.contributor.localIdA02796-
dc.contributor.localIdA03301-
dc.contributor.localIdA03490-
dc.contributor.localIdA03996-
dc.contributor.localIdA04053-
dc.relation.journalcodeJ00460-
dc.identifier.eissn1475-2840-
dc.identifier.pmidYKL-40 ; Coronary artery disease ; Type 2 diabetes-
dc.subject.keywordYKL-40-
dc.subject.keywordCoronary artery disease-
dc.subject.keywordType 2 diabetes-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKim, Won Jin-
dc.contributor.alternativeNameKim, Hyun Min-
dc.contributor.alternativeNameSong, Young Mi-
dc.contributor.alternativeNameLee, Byung Wan-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameChang, Hyuck Jae-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorKim, Won Jin-
dc.contributor.affiliatedAuthorKim, Hyun Min-
dc.contributor.affiliatedAuthorSong, Young Mi-
dc.contributor.affiliatedAuthorLee, Byung Wan-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.contributor.affiliatedAuthorChang, Hyuck Jae-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage84-
dc.identifier.bibliographicCitationCARDIOVASCULAR DIABETOLOGY, Vol.11(1) : 84, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.