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Outcomes of cardiac involvement in patients with late-stage Duchenne muscular dystrophy under management in the pulmonary rehabilitation center of a tertiary referral hospital.
DC Field | Value | Language |
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dc.contributor.author | 임세중 | - |
dc.contributor.author | 최의영 | - |
dc.contributor.author | 강성웅 | - |
dc.contributor.author | 권성우 | - |
dc.contributor.author | 권혁문 | - |
dc.contributor.author | 김종윤 | - |
dc.contributor.author | 윤영원 | - |
dc.date.accessioned | 2014-12-19T16:37:43Z | - |
dc.date.available | 2014-12-19T16:37:43Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0008-6312 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89888 | - |
dc.description.abstract | OBJECTIVES: The purpose of this study was to investigate the clinical outcome as well as the sequential changes of cardiac function in late-stage Duchenne muscular dystrophy (DMD) patients by 2-dimensional echocardiography. METHODS: A total of 31 individuals (initial age: 21.6 ± 5.0 years, range: 15-35 years) with late-stage DMD (Swinyard-Deaver's stage 7 or 8) were enrolled. All of these patients had respiratory insufficiency and were on ventilator support. Sequential echocardiographic data were collected over at least 3 years. Repeated measures analysis of variance was used to compare changes in left ventricular ejection fraction (LVEF) over time. RESULTS: The sequential change in the mean LVEF showed no significant differences with initial, 1-, 2-, and 3-year follow-up LVEFs which were 42.2, 42.9, 43.8 and 42.6%, respectively (p = 0.320). In terms of the clinical outcome, all but 1 patient survived during the follow-up period of 46.5 ± 9.1 months. CONCLUSIONS: The cardiac function in late-stage DMD patients showed a stabilization of LVEF on adequate ventilatory support and optimal cardiac medication therapy until their mid-30s. In addition, considering the favorable clinical outcome in our study, the process of cardiac involvement in late-stage DMD may demonstrate that in some patients it is nonprogressive. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Echocardiography | - |
dc.subject.MESH | Electrocardiography | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart Diseases/diagnostic imaging | - |
dc.subject.MESH | Heart Diseases/etiology* | - |
dc.subject.MESH | Heart Diseases/therapy | - |
dc.subject.MESH | Hospitalization | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Muscular Dystrophy, Duchenne/complications* | - |
dc.subject.MESH | Muscular Dystrophy, Duchenne/diagnostic imaging | - |
dc.subject.MESH | Muscular Dystrophy, Duchenne/therapy | - |
dc.subject.MESH | Positive-Pressure Respiration | - |
dc.subject.MESH | Rehabilitation Centers | - |
dc.subject.MESH | Stroke Volume | - |
dc.subject.MESH | Ventricular Dysfunction, Left | - |
dc.subject.MESH | Young Adult | - |
dc.title | Outcomes of cardiac involvement in patients with late-stage Duchenne muscular dystrophy under management in the pulmonary rehabilitation center of a tertiary referral hospital. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Rehabilitation Medicine (재활의학) | - |
dc.contributor.googleauthor | Kwon S.W. | - |
dc.contributor.googleauthor | Kang S.-W. | - |
dc.contributor.googleauthor | Kim J.-Y. | - |
dc.contributor.googleauthor | Choi E.-Y. | - |
dc.contributor.googleauthor | Yoon Y.W. | - |
dc.contributor.googleauthor | Park Y.M. | - |
dc.contributor.googleauthor | Ma D.W. | - |
dc.contributor.googleauthor | Chung H. | - |
dc.contributor.googleauthor | Kwon H.M. | - |
dc.contributor.googleauthor | Rim S.-J. | - |
dc.identifier.doi | 22508382 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03372 | - |
dc.contributor.localId | A04165 | - |
dc.contributor.localId | A00041 | - |
dc.contributor.localId | A00220 | - |
dc.contributor.localId | A00260 | - |
dc.contributor.localId | A00926 | - |
dc.contributor.localId | A02580 | - |
dc.relation.journalcode | J00457 | - |
dc.identifier.eissn | 1421-9751 | - |
dc.identifier.pmid | 22508382 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/336810 | - |
dc.subject.keyword | Duchenne muscular dystrophy | - |
dc.subject.keyword | Left ventricular ejection fraction | - |
dc.subject.keyword | Cardiac involvement | - |
dc.subject.keyword | Dilated cardiomyopathy | - |
dc.subject.keyword | Echocardiography | - |
dc.contributor.alternativeName | Rim, Se Joong | - |
dc.contributor.alternativeName | Choi, Eui Young | - |
dc.contributor.alternativeName | Kang, Seong Woong | - |
dc.contributor.alternativeName | Kwon, Sung Woo | - |
dc.contributor.alternativeName | Kwon, Hyuck Moon | - |
dc.contributor.alternativeName | Kim, Jong Youn | - |
dc.contributor.alternativeName | Yoon, Young Won | - |
dc.contributor.affiliatedAuthor | Rim, Se Joong | - |
dc.contributor.affiliatedAuthor | Choi, Eui Young | - |
dc.contributor.affiliatedAuthor | Kang, Seong Woong | - |
dc.contributor.affiliatedAuthor | Kwon, Sung Woo | - |
dc.contributor.affiliatedAuthor | Kwon, Hyuck Moon | - |
dc.contributor.affiliatedAuthor | Kim, Jong Youn | - |
dc.contributor.affiliatedAuthor | Yoon, Young Won | - |
dc.citation.volume | 121 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 186 | - |
dc.citation.endPage | 193 | - |
dc.identifier.bibliographicCitation | CARDIOLOGY, Vol.121(3) : 186-193, 2012 | - |
dc.identifier.rimsid | 31965 | - |
dc.type.rims | ART | - |
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