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Serum high mobility group box-1 is a powerful diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma.

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dc.contributor.author송시영-
dc.contributor.author이경주-
dc.contributor.author임종백-
dc.contributor.author장선필-
dc.contributor.author정혜원-
dc.date.accessioned2014-12-19T16:37:30Z-
dc.date.available2014-12-19T16:37:30Z-
dc.date.issued2012-
dc.identifier.issn1347-9032-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89881-
dc.description.abstractExtracellular high mobility group box-1 (HMGB1) contributes to tumor growth and invasiveness. We evaluated the diagnostic and prognostic ability of serum HMGB1 for pancreatic ductal adenocarcinoma (PDAC). Serum HMGB1 measured by enzyme-linked immunosorbent assay (ELISA) were compared among normal, chronic pancreatitis, PDAC group in both training (n = 25, each group) and independent validation set (n = 45, each group). To determine the usability of serum HMGB1 as a diagnostic predictor of PDAC, receiver operating characteristic (ROC) curves with sensitivity/specificity and logistic regression were evaluated. To assess the HMGB1-associated prognosis of PDAC, Kaplan-Meier survival and Cox proportional-hazards regression were applied. Serum HMGB1 was correlated with presence and advanced-stage of PDAC. Logistic regression exhibited serum HMGB1 was a remarkable biomarker to predict PDAC as a single or multiple-markers; sensitivity/specificity of serum HMGB1 were superior to carbohydrate antigen (CA) 19-9 or carcinoembryonic antigen (CEA) in both training and independent datasets. Kaplan-Meier survival analysis showed PDAC patients with high serum HMGB1 levels (>30 ng/mL; median survival, 192 days) had a worse prognosis than patients with low HMGB1 levels (≤30 ng/mL; 514 days) by log-rank (P = 0.017). Cox proportional-hazards model showed the relative hazard ratios in high-serum HMGB1 group was 3.077 compared with the low-serum HMGB1 group. In conclusion, serum HMGB1 is a desirable diagnostic and prognostic biomarker for PDAC compared with pre-existing PDAC biomarkers, CA19-9 and CEA.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCANCER SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSerum high mobility group box-1 is a powerful diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorHye Won Chung-
dc.contributor.googleauthorJong-Baeck Lim-
dc.contributor.googleauthorSunphil Jang-
dc.contributor.googleauthorKyong Joo Lee-
dc.contributor.googleauthorKyung Hwa Park-
dc.contributor.googleauthorSi Young Song-
dc.identifier.doi10.1111/j.1349-7006.2012.02358.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02035-
dc.contributor.localIdA02656-
dc.contributor.localIdA03403-
dc.contributor.localIdA03782-
dc.contributor.localIdA03433-
dc.relation.journalcodeJ00454-
dc.identifier.eissn1349-7006-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2012.02358.x/abstract-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.alternativeNameLee, Kyong Joo-
dc.contributor.alternativeNameLim, Jong Baeck-
dc.contributor.alternativeNameJang, Sun Phil-
dc.contributor.alternativeNameChung, Hye Won-
dc.contributor.affiliatedAuthorSong, Si Young-
dc.contributor.affiliatedAuthorLee, Kyong Joo-
dc.contributor.affiliatedAuthorLim, Jong Baeck-
dc.contributor.affiliatedAuthorChung, Hye Won-
dc.contributor.affiliatedAuthorJang, Sun Phil-
dc.citation.volume103-
dc.citation.number9-
dc.citation.startPage1714-
dc.citation.endPage1721-
dc.identifier.bibliographicCitationCANCER SCIENCE, Vol.103(9) : 1714-1721, 2012-
dc.identifier.rimsid31961-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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