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Adenosine triphosphate-based chemotherapy response assay-guided chemotherapy in unresectable colorectal liver metastasis.

Authors
 H Hur  ;  NK Kim  ;  HG Kim  ;  BS Min  ;  KY Lee  ;  SJ Shin  ;  JH Cheon  ;  SH Choi 
Citation
 British Journal of Cancer, Vol.106(1) : 53-60, 2012 
Journal Title
 British Journal of Cancer 
ISSN
 0007-0920 
Issue Date
2012
Abstract
BACKGROUND: This study aims to evaluate the effectiveness of adenosine triphosphate-based chemotherapy response assay (ATP-CRA)-guided neoadjuvant chemotherapy for increasing resectability in patients with unresectable colorectal liver metastasis. PATIENTS AND METHODS: Patients were randomised into two groups: Group A was treated by conventional chemotherapy regimen and Group B was treated by chemotherapy regimen according to the ATP-CRA. Three chemotherapeutic agents (5-fluorouracil, oxaliplatin and irinotecan) were tested by ATP-CRA and more sensitive agents were selected. Either FOLFOX or FOLFIRI was administered. Between Group A and B, treatment response and resectability were compared. RESULTS: Between November 2008 and October 2010, a total 63 patients were randomised to Group A (N=32) or Group B (N=31). FOLFOX was more preferred in Group A than in Group B (26 out of 32 (81.3%) vs 20 out of 31 (64.5%)). Group B showed better treatment response than Group A (48.4% vs 21.9%, P=0.027). The resectability of hepatic lesion was higher in Group B (35.5% vs 12.5%, P=0.032). Mean duration from chemotherapy onset to the time of liver resection was 11 cycles (range 4-12) in Group A and 8 cycles (range 8-16) in Group B. CONCLUSION: This study showed that tailored-chemotherapy based on ATP-CRA could improve the treatment response and resectability in initially unresectable colorectal liver metastasis.
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DOI
10.1038/bjc.2011.469
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
김남규(Kim, Nam Kyu) ORCID logo https://orcid.org/0000-0003-0639-5632
김호근(Kim, Ho Keun)
민병소(Min, Byung Soh)
신상준(Shin, Sang Joon) ORCID logo https://orcid.org/0000-0001-5350-7241
이강영(Lee, Kang Young)
천재희(Cheon, Jae Hee) ORCID logo https://orcid.org/0000-0002-2282-8904
허혁(Hur, Hyuk) ORCID logo https://orcid.org/0000-0002-9864-7229
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89825
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