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Retinal protective effects of topically administered agmatine on ischemic ocular injury caused by transient occlusion of the ophthalmic artery.
DC Field | Value | Language |
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dc.contributor.author | 김찬윤 | - |
dc.contributor.author | 성공제 | - |
dc.contributor.author | 홍사민 | - |
dc.date.accessioned | 2014-12-19T16:35:06Z | - |
dc.date.available | 2014-12-19T16:35:06Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0100-879X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89806 | - |
dc.description.abstract | Agmatine, an endogenous polyamine and putative neuromodulator, is known to have neuroprotective effects on various neurons in the central nervous system. We determined whether or not topically administered agmatine could reduce ischemic retinal injury. Transient ocular ischemia was achieved by intraluminal occlusion of the middle cerebral artery of ddY mice (30-35 g) for 2 h, which is known to also induce occlusion of the ophthalmic artery. In the agmatine group (N = 6), a 1.0 mM agmatine-containing ophthalmic solution was administered four times daily for 2 weeks before occlusion. In the control group (N = 6), a 0.1% hyaluronic acid ophthalmic solution was instilled at the same times. At 22 h after reperfusion, the eyeballs were enucleated and the retinal sections were stained by terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL). Transient ocular ischemia induced apoptosis of retinal cells in the entire retinal layer, and topically administered agmatine can significantly reduce this ischemic retinal injury. The proportion of apoptotic cells was definitely decreased (P < 0.001; Kruskal-Wallis test). Overall, we determined that topical agmatine application effectively decreases retinal damage in an in vivo ocular ischemic injury model. This implies that agmatine is a good candidate as a direct neuroprotective agent for eyes with ocular ischemic diseases. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Agmatine/administration & dosage* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Arterial Occlusive Diseases/complications* | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Ischemia/drug therapy* | - |
dc.subject.MESH | Ischemia/etiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Neuroprotective Agents/administration & dosage* | - |
dc.subject.MESH | Ophthalmic Artery* | - |
dc.subject.MESH | Retinal Diseases/drug therapy* | - |
dc.subject.MESH | Retinal Diseases/etiology | - |
dc.title | Retinal protective effects of topically administered agmatine on ischemic ocular injury caused by transient occlusion of the ophthalmic artery. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학) | - |
dc.contributor.googleauthor | S. Hong | - |
dc.contributor.googleauthor | H. Hara | - |
dc.contributor.googleauthor | M. Shimazawa | - |
dc.contributor.googleauthor | K. Hyakkoku | - |
dc.contributor.googleauthor | C.Y. Kim | - |
dc.contributor.googleauthor | G.J. Seong | - |
dc.identifier.doi | 22331138 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01035 | - |
dc.contributor.localId | A01946 | - |
dc.contributor.localId | A04395 | - |
dc.relation.journalcode | J00399 | - |
dc.identifier.eissn | 1414-431X | - |
dc.identifier.pmid | 22331138 | - |
dc.subject.keyword | Agmatine | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Ischemia | - |
dc.subject.keyword | Neuroprotection | - |
dc.subject.keyword | Retina | - |
dc.contributor.alternativeName | Kim, Chan Yun | - |
dc.contributor.alternativeName | Seong, Gong Je | - |
dc.contributor.alternativeName | Hong, Sa Min | - |
dc.contributor.affiliatedAuthor | Kim, Chan Yun | - |
dc.contributor.affiliatedAuthor | Seong, Gong Je | - |
dc.contributor.affiliatedAuthor | Hong, Sa Min | - |
dc.citation.volume | 45 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 212 | - |
dc.citation.endPage | 215 | - |
dc.identifier.bibliographicCitation | BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, Vol.45(3) : 212-215, 2012 | - |
dc.identifier.rimsid | 31918 | - |
dc.type.rims | ART | - |
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