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Effects of lamotrigine on cognition and behavior compared to carbamazepine as monotherapy for children with partial epilepsy.

 So-Hee Eun  ;  Baik-Lin Eun  ;  Joon Soo Lee  ;  Yong Seung Hwang  ;  Ki Joong Kim  ;  Young-Mock Lee  ;  In Goo Lee  ;  Munhyang Lee  ;  Tae-Sung Ko  ;  Jeong Tae Kim  ;  Soyong Eom  ;  Heung Dong Kim 
 BRAIN & DEVELOPMENT, Vol.34(10) : 818-823, 2012 
Journal Title
Issue Date
Anticonvulsants/therapeutic use* ; Behavior/drug effects* ; Carbamazepine/therapeutic use* ; Child ; Cognition/drug effects* ; Epilepsies, Partial/drug therapy* ; Female ; Humans ; Male ; Treatment Outcome ; Triazines/therapeutic use*
Lamotrigine ; Cognition ; Behavior ; ChildPartial epilepsy
To compare the cognitive and behavioral effects of lamotrigine (LTG) to carbamazepine (CBZ) as monotherapy for pediatric epilepsy. A multicenter, randomized, open-label, parallel-group clinical trial was conducted in children with partial-onset seizures. LTG or CBZ was prescribed as monotherapy for previously untreated children and titrated over 8 weeks, followed by maintenance for 24 weeks. Outcome measures were change in cognition and behavior in a combined analysis of standardized measures from screening to the end of the maintenance phase, as well as antiepileptic efficacy and tolerability. A total of 67 children completed the study, including 32 of 43 (74.4%) treated with LTG and 35 of 41 (85.4%) treated with CBZ. Seizure-free outcomes did not differ between the intent-to-treat populations (53.5% LTG, 56.1% CBZ; p=0.81). There were no statistically significant differences in the intelligence of the two groups after treatment. Externalizing behavior problems improved in the CBZ group (p<0.05). However, there were no significant differences between the two groups in terms of externalizing behavior. The parents' report on the Conner scale showed an improvement in the CBZ group compared to the LTG group (p<0.05). LTG and CBZ showed similar efficacy and cognitive effects in treating childhood partial epilepsy. However, CBZ showed more benefits in improving externalizing behaviors.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
Lee, Young Mock(이영목) ORCID logo https://orcid.org/0000-0002-5838-249X
Lee, Joon Soo(이준수) ORCID logo https://orcid.org/0000-0001-9036-9343
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