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Various indications for a modified Atkins diet in intractable childhood epilepsy.

Authors
 Yoon Mi Kim  ;  Varsha Viranchi Vaidy  ;  Timur Khusainov  ;  Heung Dong Kim  ;  Shin-Hye Kim  ;  Eun Joo Lee  ;  Young Mock Lee  ;  Joon Soo Lee  ;  Hoon-Chul Kang 
Citation
 BRAIN & DEVELOPMENT, Vol.34(7) : 570-575, 2012 
Journal Title
 BRAIN & DEVELOPMENT 
ISSN
 0387-7604 
Issue Date
2012
MeSH
Adolescent ; Child ; Child, Preschool ; Diet, Carbohydrate-Restricted*/adverse effects ; Diet, Ketogenic* ; Epilepsy/complications ; Epilepsy/diet therapy* ; Female ; Humans ; Male ; Retrospective Studies ; Treatment Outcome
Keywords
Modified Atkins diet ; Intractable childhood epilepsy
Abstract
PURPOSE: We reviewed retrospectively our experiences with children with intractable epilepsy who were indicated for a modified Atkins diet (MAD). METHODS: Twenty children (8 female, 12 male) who were aged 2-17 years with intractable epilepsy and tried the MAD between September 2008 and December 2010 were enrolled. Outcome measures included seizure frequency, adverse reactions and tolerability of the diet. RESULTS: Finally 9 patients maintained the MAD with favorable seizure outcomes (a reduction of seizure frequency by over 50%) or successfully completed the diet therapy. Two patients who required a long-term trial of the diet therapy respectively due to Leigh's syndrome and uncategorized mitochondrial cytopathy derived from cytochrome c oxidase defect, respectively, successfully maintained the diet treatment without any significant complications. In 7 patients, the ketogenic diet (KD) was not only effective but also too restrictive or caused serious unwanted events. Five of them maintained the seizure outcome previously achieved by the KD with the MAD. Ten patients began the MAD because they were reluctant to start the KD. Unfortunately, only 2 patients maintained the MAD with favorable seizure outcomes. One patient who chose the MAD to bridge the KD and complete discontinuation of the treatment successfully completed the diet therapy. CONCLUSION: A long-term treatment with the MAD was well tolerated. Moreover, the MAD can successfully substitute the classic KD in patients who showed improvement in seizure outcomes by the KD but could not tolerate it.
Full Text
http://www.sciencedirect.com/science/article/pii/S0387760411002889
DOI
22001499
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hoon Chul(강훈철) ORCID logo https://orcid.org/0000-0002-3659-8847
Kim, Shin Hye(김신혜)
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
Lee, Young Mock(이영목) ORCID logo https://orcid.org/0000-0002-5838-249X
Lee, Joon Soo(이준수) ORCID logo https://orcid.org/0000-0001-9036-9343
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89801
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