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Kalopanaxsaponin A inhibits the invasion of human oral squamous cell carcinoma by reducing metalloproteinase-9 mRNA stability and protein trafficking
DC Field | Value | Language |
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dc.contributor.author | 정원윤 | - |
dc.contributor.author | 황영선 | - |
dc.contributor.author | 박광균 | - |
dc.date.accessioned | 2014-12-19T16:32:19Z | - |
dc.date.available | 2014-12-19T16:32:19Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89719 | - |
dc.description.abstract | An inability to control cancer cell invasion and metastasis is the leading cause of death in patients with cancer. The present study was performed to determine the anti-invasive effect of Kalopanaxsaponin A (KPS-A) on matrix metalloproteinase-9 (MMP-9)-meidated invasion in phorbol 12-myristate 13-acetate (PMA)-stimulated human oral squamous cell carcinoma (OSCC) cells and a murine xenograft model of human OSCC. KPS-A, isolated from Kalopanax pictus, inhibited PMA-induced proliferation and invasion as well as PMA-induced MMP-9 expression and secretion at non-cytotoxic doses. KPS-A treatment reduced the stability of PMA-induced MMP-9 mRNA and inhibited the PMA-induced cytoplasmic translocation of HuR. In PMA-treated cells, KPS-A treatment resulted in the intracellular accumulation of MMP-9 and suppressed Ras-associated binding 1A (Rab1A) expression. KPS-A treatment suppressed PMA-induced phosphorylation of extracellular signal regulated kinase (ERK)1/2 and Akt. Furthermore, the oral administration of KPS-A led to substantial inhibition of tumor growth and the expression of proliferating cell nuclear antigen (PCNA), MMP-9, tissue inhibitor of metalloproteinase-1 (TIMP-1), HuR, and Rab1A in the tumor tissues of mice inoculated with YD-10B OSCC cells. Collectively, KPS-A inhibits the invasiveness of oral cancer by reducing HuR-mediated MMP-9 mRNA stability and Rab1A-mediated MMP-9 secretion via ERK1/2 and phosphatidylinositide 3-kinase (PI3K)/Akt. Therefore, KPS-A is a promising anti-invasive agent. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antineoplastic Agents, Phytogenic/pharmacology | - |
dc.subject.MESH | Antineoplastic Agents, Phytogenic/therapeutic use* | - |
dc.subject.MESH | Carcinoma, Squamous Cell/drug therapy* | - |
dc.subject.MESH | Carcinoma, Squamous Cell/metabolism | - |
dc.subject.MESH | Carcinoma, Squamous Cell/pathology | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Matrix Metalloproteinase 9/genetics | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Mouth Neoplasms/pathology | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Oleanolic Acid/analogs & derivatives* | - |
dc.subject.MESH | Oleanolic Acid/pharmacology | - |
dc.subject.MESH | Oleanolic Acid/therapeutic use | - |
dc.subject.MESH | Protein Transport/drug effects | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Saponins/pharmacology | - |
dc.subject.MESH | Saponins/therapeutic use* | - |
dc.subject.MESH | Tetradecanoylphorbol Acetate/pharmacology | - |
dc.subject.MESH | Tumor Burden/drug effects | - |
dc.subject.MESH | Xenograft Model Antitumor Assays | - |
dc.title | Kalopanaxsaponin A inhibits the invasion of human oral squamous cell carcinoma by reducing metalloproteinase-9 mRNA stability and protein trafficking | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Oral Cancer Research Institute (구강종양연구소) | - |
dc.contributor.googleauthor | Young Sun Hwang | - |
dc.contributor.googleauthor | Kwang-Kyun Park | - |
dc.contributor.googleauthor | Won-Yoon Chung | - |
dc.identifier.doi | 22382313 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03676 | - |
dc.contributor.localId | A04472 | - |
dc.contributor.localId | A01429 | - |
dc.relation.journalcode | J00300 | - |
dc.identifier.eissn | 1347-5215 | - |
dc.identifier.pmid | 22382313 | - |
dc.subject.keyword | Kalopanaxsaponin-A | - |
dc.subject.keyword | oral cancer | - |
dc.subject.keyword | anti-invasive effect | - |
dc.subject.keyword | metalloproteinase-9 | - |
dc.subject.keyword | HuR | - |
dc.subject.keyword | Ras-associated binding 1A | - |
dc.contributor.alternativeName | Chung, Won Yoon | - |
dc.contributor.alternativeName | Hwang, Young Sun | - |
dc.contributor.alternativeName | Park, Kwang Kyun | - |
dc.contributor.affiliatedAuthor | Chung, Won Yoon | - |
dc.contributor.affiliatedAuthor | Hwang, Young Sun | - |
dc.contributor.affiliatedAuthor | Park, Kwang Kyun | - |
dc.citation.volume | 35 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 289 | - |
dc.citation.endPage | 300 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, Vol.35(3) : 289-300, 2012 | - |
dc.identifier.rimsid | 31867 | - |
dc.type.rims | ART | - |
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