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Kalopanaxsaponin A inhibits the invasion of human oral squamous cell carcinoma by reducing metalloproteinase-9 mRNA stability and protein trafficking

DC FieldValueLanguage
dc.contributor.author정원윤-
dc.contributor.author황영선-
dc.contributor.author박광균-
dc.date.accessioned2014-12-19T16:32:19Z-
dc.date.available2014-12-19T16:32:19Z-
dc.date.issued2012-
dc.identifier.issn0918-6158-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89719-
dc.description.abstractAn inability to control cancer cell invasion and metastasis is the leading cause of death in patients with cancer. The present study was performed to determine the anti-invasive effect of Kalopanaxsaponin A (KPS-A) on matrix metalloproteinase-9 (MMP-9)-meidated invasion in phorbol 12-myristate 13-acetate (PMA)-stimulated human oral squamous cell carcinoma (OSCC) cells and a murine xenograft model of human OSCC. KPS-A, isolated from Kalopanax pictus, inhibited PMA-induced proliferation and invasion as well as PMA-induced MMP-9 expression and secretion at non-cytotoxic doses. KPS-A treatment reduced the stability of PMA-induced MMP-9 mRNA and inhibited the PMA-induced cytoplasmic translocation of HuR. In PMA-treated cells, KPS-A treatment resulted in the intracellular accumulation of MMP-9 and suppressed Ras-associated binding 1A (Rab1A) expression. KPS-A treatment suppressed PMA-induced phosphorylation of extracellular signal regulated kinase (ERK)1/2 and Akt. Furthermore, the oral administration of KPS-A led to substantial inhibition of tumor growth and the expression of proliferating cell nuclear antigen (PCNA), MMP-9, tissue inhibitor of metalloproteinase-1 (TIMP-1), HuR, and Rab1A in the tumor tissues of mice inoculated with YD-10B OSCC cells. Collectively, KPS-A inhibits the invasiveness of oral cancer by reducing HuR-mediated MMP-9 mRNA stability and Rab1A-mediated MMP-9 secretion via ERK1/2 and phosphatidylinositide 3-kinase (PI3K)/Akt. Therefore, KPS-A is a promising anti-invasive agent.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfBiological & Pharmaceutical Bulletin-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleKalopanaxsaponin A inhibits the invasion of human oral squamous cell carcinoma by reducing metalloproteinase-9 mRNA stability and protein trafficking-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentOral Cancer Research Institute (구강종양연구소)-
dc.contributor.googleauthorYoung Sun Hwang-
dc.contributor.googleauthorKwang-Kyun Park-
dc.contributor.googleauthorWon-Yoon Chung-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03676-
dc.contributor.localIdA04472-
dc.contributor.localIdA01429-
dc.relation.journalcodeJ00300-
dc.contributor.alternativeNameChung, Won Yoon-
dc.contributor.alternativeNameHwang, Young Sun-
dc.contributor.alternativeNamePark, Kwang Kyun-
dc.contributor.affiliatedAuthorChung, Won Yoon-
dc.contributor.affiliatedAuthorHwang, Young Sun-
dc.contributor.affiliatedAuthorPark, Kwang Kyun-
dc.citation.volume35-
dc.citation.number3-
dc.citation.startPage289-
dc.citation.endPage300-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, Vol.35(3) : 289-300, 2012-
Appears in Collections:
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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