Cited 24 times in

101 3

Statins use and coronary artery plaque composition: results from the International Multicenter CONFIRM Registry.

Authors
 Ryo Nakazato ; Heidi Gransar ; James K. Min ; Jonathon Leipsic ; Yong-Jin Kim ; Gudrun Feuchtner ; Allison Dunninge ; Todd C. Villines ; Leslee J. Shaw ; Gilbert Raff ; Erica Maffei ; Philipp Kaufmann ; Joerg Hausleiter ; Martin Hadamitzky ; Augustin Delago ; Benjamin J.W. Chow ; Kavitha Chinnaiyan ; Ricardo C. Cury ; Hyuk-Jae Chang ; Tracy Q. Callister ; Filippo Cademartiri ; Matthew J. Budoff ; Mouaz Al-Mallah ; Stephan Achenbach ; Fay Y. Lin ; Victor Y. Cheng ; Daniel S. Berman 
Citation
 Atherosclerosis, Vol.225(1) : 148~153, 2012 
Journal Title
 Atherosclerosis 
ISSN
 0021-9150 
Issue Date
2012
Abstract
OBJECTIVE: The effect of statins on coronary artery plaque features beyond stenosis severity is not known. Coronary CT angiography (CCTA) is a novel non-invasive method that permits direct visualization of coronary atherosclerotic features, including plaque composition. We evaluated the association of statin use to coronary plaque composition type in patients without known coronary artery disease (CAD) undergoing CCTA. METHODS: From consecutive individuals, we identified 6673 individuals (2413 on statin therapy and 4260 not on statin therapy) with no known CAD and available statin use status. We studied the relationship between statin use and the presence and extent of specific plaque composition types, which was graded as non-calcified (NCP), mixed (MP), or calcified (CP) plaque. RESULTS: The mean age was 59 ± 11 (55% male). Compared to the individuals not taking statins, those taking statins had higher prevalence of risk factors and obstructive CAD. In multivariable analyses, statin use was associated with increased the presence of MP [odds ratio (OR) 1.46, 95% confidence interval (CI) 1.27-1.68), p < 0.001] and CP (OR 1.54, 95% CI 1.36-1.74, p < 0.001), but not NCP (OR 1.11, 95% CI 0.96-1.29, p = 0.1). Further, in multivariable analyses, statin use was associated with increasing numbers of coronary segments possessing MP (OR 1.52, 95% CI 1.34-1.73, p < 0.001) and CP (OR 1.52, 95% CI 1.36-1.70, p < 0.001), but not coronary segments with NCP (OR 1.09, 95% CI 0.94-1.25, p = 0.2). CONCLUSION: Statin use is associated with an increased prevalence and extent of coronary plaques possessing calcium. The longitudinal effect of statins on coronary plaque composition warrants further investigation
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/89673
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://www.sciencedirect.com/science/article/pii/S0021915012005229
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse