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Inverse relationship between bioavailable testosterone and subclinical coronary artery calcification in non-obese Korean men

DC Field Value Language
dc.contributor.author이용제-
dc.contributor.author이혜리-
dc.contributor.author박병진-
dc.contributor.author심재용-
dc.date.accessioned2014-12-19T16:29:47Z-
dc.date.available2014-12-19T16:29:47Z-
dc.date.issued2012-
dc.identifier.issn1008-682X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89638-
dc.description.abstractAlthough low testosterone levels in men have been associated with high risk for cardiovascular disease, little is known about the association between male sex hormones and subclinical coronary disease in men with apparently low cardiometabolic risk. This study was performed to investigate the association between male sex hormones and subclinical coronary artery calcification measured as coronary calcium score in non-obese Korean men. We examined the relationship of total testosterone, sex hormone-binding globulin, bioavailable testosterone and free testosterone with coronary calcium score in 291 non-obese Korean men (mean age: 52.8±9.3 years) not having a history of cardiovascular disease. Using multiple linear regression, we evaluated associations between log (sex hormone) levels and log (coronary calcium score) after adjusting for confounding variables in 105 men with some degree of coronary calcification defined as coronary calcium score ≥ 1. In multiple linear regression analysis, bioavailable testosterone was inversely associated with coronary calcium score (P=0.046) after adjusting for age, body mass index, smoking status, alcohol consumption, regular exercise, mean blood pressure, resting heart rate, C-reactive protein, fasting plasma glucose, total cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, hypertension medication and hyperlipidemia medication, whereas total testosterone, sex hormone-binding globulin and free testosterone were not (P=0.674, P=0.121 and P=0.102, respectively). Our findings indicate that bioavailable testosterone is inversely associated with the degree of subclinical coronary artery calcification in non-obese men.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfASIAN JOURNAL OF ANDROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHCalcium/metabolism-
dc.subject.MESHCardiovascular Diseases/blood-
dc.subject.MESHCardiovascular Diseases/physiopathology-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHCoronary Vessels/metabolism-
dc.subject.MESHCoronary Vessels/physiopathology*-
dc.subject.MESHHumans-
dc.subject.MESHLinear Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSex Hormone-Binding Globulin/metabolism-
dc.subject.MESHTestosterone/blood*-
dc.subject.MESHTestosterone/physiology-
dc.subject.MESHVascular Calcification/blood*-
dc.subject.MESHVascular Calcification/physiopathology-
dc.titleInverse relationship between bioavailable testosterone and subclinical coronary artery calcification in non-obese Korean men-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학)-
dc.contributor.googleauthorByoung-Jin Park-
dc.contributor.googleauthorJae-Yong Shim-
dc.contributor.googleauthorYong-Jae Lee-
dc.contributor.googleauthorJung-Hyun Lee-
dc.contributor.googleauthorHye-Ree Lee-
dc.identifier.doi10.1038/aja.2012.19-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02982-
dc.contributor.localIdA01477-
dc.contributor.localIdA02207-
dc.contributor.localIdA03310-
dc.relation.journalcodeJ00250-
dc.identifier.eissn1745-7262-
dc.identifier.pmid22522505-
dc.subject.keywordbioavailable testosterone-
dc.subject.keywordcardiovascular disease-
dc.subject.keywordcoronary calcium score-
dc.subject.keywordmale sex hormone-
dc.subject.keywordsubclinical coronary artery disease-
dc.subject.keywordtestosterone-
dc.contributor.alternativeNameLee, Yong Jae-
dc.contributor.alternativeNameLee, Hye Ree-
dc.contributor.alternativeNamePark, Byoung Jin-
dc.contributor.alternativeNameShim, Jae Yong-
dc.contributor.affiliatedAuthorLee, Yong Jae-
dc.contributor.affiliatedAuthorPark, Byoung Jin-
dc.contributor.affiliatedAuthorShim, Jae Yong-
dc.contributor.affiliatedAuthorLee, Hye Ree-
dc.citation.volume14-
dc.citation.number4-
dc.citation.startPage612-
dc.citation.endPage615-
dc.identifier.bibliographicCitationASIAN JOURNAL OF ANDROLOGY, Vol.14(4) : 612-615, 2012-
dc.identifier.rimsid31822-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

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