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Influx of multidrug resistant, Gram-negative bacteria (MDRGNB) in a public hospital among elderly patients from long-term care facilities: a single-center pilot study

Authors
 Jae-Phil Choi  ;  Eun Ha Cho  ;  Seung Joon Lee  ;  Seung Tae Lee  ;  Myung Sook Koo  ;  Young-Goo Song 
Citation
 ARCHIVES OF GERONTOLOGY AND GERIATRICS, Vol.54(2) : 19-22, 2012 
Journal Title
ARCHIVES OF GERONTOLOGY AND GERIATRICS
ISSN
 0167-4943 
Issue Date
2012
MeSH
Aged ; Aged, 80 and over ; Cross Infection/epidemiology ; Cross Infection/etiology ; Cross Infection/microbiology ; Cross Infection/transmission* ; Drug Resistance, Multiple, Bacterial ; Female ; Gram-Negative Bacterial Infections/epidemiology ; Gram-Negative Bacterial Infections/etiology ; Gram-Negative Bacterial Infections/microbiology ; Gram-Negative Bacterial Infections/transmission* ; Hospitals, Public* ; Hospitals, Teaching ; Humans ; Long-Term Care ; Male ; Microbial Sensitivity Tests ; Pilot Projects ; Prevalence ; Republic of Korea/epidemiology
Keywords
Aged ; Aged, 80 and over ; Cross Infection/epidemiology ; Cross Infection/etiology ; Cross Infection/microbiology ; Cross Infection/transmission* ; Drug Resistance, Multiple, Bacterial ; Female ; Gram-Negative Bacterial Infections/epidemiology ; Gram-Negative Bacterial Infections/etiology ; Gram-Negative Bacterial Infections/microbiology ; Gram-Negative Bacterial Infections/transmission* ; Hospitals, Public* ; Hospitals, Teaching ; Humans ; Long-Term Care ; Male ; Microbial Sensitivity Tests ; Pilot Projects ; Prevalence ; Republic of Korea/epidemiology
Abstract
Residence at a long-term care facility (LTCF) and older age are both recognized as significant risk factors for harboring MDRGNB. However, well designed prospective observational studies are few on the prevalence and risk factors of MDRGNB influx to hospital due to elderly patients arriving from LTCFs. Between November 1 and December 31, 2009, at a 500-bed, public teaching hospital in Seoul, Republic of Korea, all clinical cultures within 48 h of hospitalization from elderly patients at least 50 years of age arriving from LTCFs were collected prospectively. During these periods, the prevalence of MDRGNB influx among elderly patients from LTCFs was higher than that among other hospitalized patients (14.5% vs. 2.5%, odds ratio [OR] 8.1, 95% confidence interval [CI] 3.5-18.8, P<0.001). Of a total of 55 elderly hospitalized subjects from 6 LTCFs, clinical cultures were performed in 37. MDRGNB were found in 8 patients (6 of whom were infected). There was no difference between patients with and without MDRGNB regarding previously reported clinical characteristics associated with harboring MDRGNB. However, the mortality within one month of hospitalization was higher in patients with MDRGNB than without MDRGNB, regardless of the appropriateness of the antibiotics they received (OR, 15.91; 95% CI, 1.01-251.36; P=0.049). In conclusion, the prevalence of MDRGNB influx among elderly patients from LTCFs is significant in Korean public hospital. They require specific remedies in order to reduce the risk of early mortality.
Full Text
http://www.sciencedirect.com/science/article/pii/S0167494311001506
DOI
21764147
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89608
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