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Short-term results and long-term oncologic outcomes between neoadjuvant chemoradiotherapy and adjuvant postoperative chemoradiotherapy for stage III rectal cancer: a case-matched study

Authors
 Jeonghyun Kang  ;  Sung Min Jang  ;  Jeong-Heum Baek  ;  Won Suk Lee  ;  Tae Ho Cho 
Citation
 Annals of Surgical Oncology, Vol.19(8) : 2494-2499, 2012 
Journal Title
 Annals of Surgical Oncology 
ISSN
 1068-9265 
Issue Date
2012
Abstract
PURPOSE: To compare the short-term perioperative results and long-term oncologic outcomes between patients who underwent neoadjuvant chemoradiotherapy (NCRT) and patients who underwent postoperative adjuvant chemoradiotherapy (ACRT) for stage III rectal cancer. METHODS: From January 1997 to December 2008, a total of 47 patients who were diagnosed as clinical stage III rectal cancer followed by NCRT were matched according to age, gender, and operation method to 47 patients with pathologic stage III rectal cancer who underwent ACRT. Clinical characteristics, surgical and pathologic outcomes, postoperative complications and recovery, and oncologic outcomes were compared between the two groups. RESULTS: There were no significant differences in demographics or preoperative characteristics between the NCRT and ACRT groups. Though more protective ileostomies were performed in the NCRT group, there was no statistical difference in operation times between the two groups. Patients in the NCRT group had a smaller tumor size (P < 0.001) and a smaller number of lymph nodes retrieved (P < 0.001). No differences were observed with respect to morbidity and recovery outcomes between the two groups. During the median 58-month follow-up periods, the NCRT group showed better disease-free survival and overall survival than the ACRT group (P = 0.002, P = 0.001, respectively). CONCLUSIONS: NCRT in comparison to ACRT did not increase the risk of postoperative morbidity and provided better disease-free and overall survival in stage III rectal cancer patients.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89558
DOI
10.1245/s10434-012-2311-9
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
강정현(Kang, Jeonghyun)
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Full Text
http://link.springer.com/article/10.1245%2Fs10434-012-2311-9
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