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Frequencies and Related Factors for Microvascular Complications in Patients with Type 1 Diabetes Complications in Patients with Type 1 Diabetes

 Ah Reum Kwon  ;  Seul Lee  ;  Hyun Wook Chae  ;  Duk Hee Kim  ;  Ho-Seong Kim 
 Annals of Pediatric Endocrinology & Metabolism, Vol.17(1) : 16-26, 2012 
Journal Title
 Annals of Pediatric Endocrinology & Metabolism 
Issue Date
Purpose: We observed the frequencies of microvascular complications and their related factors in patients with type 1 diabetes. Methods: Two hundred seventy one patients (111 males and 160 females, mean age 21.9 ± 5.8 years) with type 1 diabetes were included. Subjects were all at least 10 years old and had diabetes for at least two years. Three types of microvascular complications (diabetic nephropathy, retinopathy, and neuropathy) were evaluated, and their frequencies and risk factors were analyzed. Results: The overall prevalence of microvascular disease was 83/271 (30.6%). Microalbuminuria had developed in 39 patients (14.4%), persistent microalbuminuria in 31 patients (11.4%), and proteinuria in 12 (4.4%). Diabetic retinopathy had developed in 35 patients (12.9%) and neuropathy in 39 patients (13.7%). The mean HbA1c for 10 years was significantly higher in the patients with microvascular complications (10.5 ± 2.8% vs. 8.4 ± 1.4%). The rate of intensive management in the non-complication group was higher than in the microvascular complication group. The incidence of microalbuminuria was greater in males than females, but there were no gender differences in either diabetic retinopathy or neuropathy. Puberty and the duration of diabetes may be associated with microvascular complications. Conclusion: The incidence of microvascular complications in type 1 diabetes is declining. Sex, puberty, and the duration of diabetes as well as prolonged hyperglycemia are all related to microvascular complications. Therefore, intensive insulin management and regular screening for microvascular complications should be performed in patients who have either entered into puberty or have had diabetes for more than 5 years.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
권아름(Kwon, Ah Reum) ORCID logo https://orcid.org/0000-0002-9692-2135
김호성(Kim, Ho Seong) ORCID logo https://orcid.org/0000-0003-1135-099X
채현욱(Chae, Hyun Wook) ORCID logo https://orcid.org/0000-0001-5016-8539
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