Antifungal susceptibility to amphotericin B, fluconazole, voriconazole, and flucytosine in Candida bloodstream isolates from 15 tertiary hospitals in Korea

Sook-In Jung; Jong Hee Shin; Hyun-Jung Choi; Min-Young Ju; Soo-Hyun Kim; Wee Gyo Lee; Yeon-Joon Park; Kyungwon Lee

doi:10.3343/alm.2012.32.6.426

YUHSpace

BROWSE

208 612

Cited 0 times in

Cited 18 times in

Antifungal susceptibility to amphotericin B, fluconazole, voriconazole, and flucytosine in Candida bloodstream isolates from 15 tertiary hospitals in Korea

Authors: Sook-In Jung ; Jong Hee Shin ; Hyun-Jung Choi ; Min-Young Ju ; Soo-Hyun Kim ; Wee Gyo Lee ; Yeon-Joon Park ; Kyungwon Lee

Citation: ANNALS OF LABORATORY MEDICINE, Vol.32(6) : 426-428, 2012

Journal Title: ANNALS OF LABORATORY MEDICINE

ISSN: 2234-3806

Issue Date: 2012

MeSH: Amphotericin B/pharmacology* ; Antifungal Agents/pharmacology* ; Candida/drug effects* ; Candida/isolation & purification ; Candidiasis/blood ; Candidiasis/microbiology ; Fluconazole/pharmacology* ; Flucytosine/pharmacology* ; Humans ; Microbial Sensitivity Tests ; Pyrimidines/pharmacology* ; Republic of Korea ; Tertiary Care Centers ; Triazoles/pharmacology* ; Voriconazole

Keywords: Amphotericin B ; Candida ; Fluconazole ; Flucytosine ; Voriconazole

Abstract: The in vitro antifungal susceptibility of 636 Candida bloodstream isolates collected from 15 tertiary hospitals in Korea was determined using the Vitek-2 yeast susceptibility system (bioMérieux, France). Overall susceptibility rates were 98.1%, 95.9%, 99.1%, and 97.3% for amphotericin B, fluconazole, voriconazole, and flucytosine, respectively. The results show that the rates of resistance to 4 antifungal drugs remain low among Candida bloodstream isolates in Korea.

KEYWORDS: Amphotericin B, Candida, Fluconazole, Flucytosine, Voriconazole