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Radiotherapy for solitary plasmacytoma of bone and soft tissue: outcomes and prognostic factors

DC FieldValueLanguage
dc.contributor.author김수정-
dc.contributor.author김진석-
dc.contributor.author변해옥-
dc.contributor.author서양권-
dc.contributor.author서창옥-
dc.contributor.author조재호-
dc.date.accessioned2014-12-19T16:25:39Z-
dc.date.available2014-12-19T16:25:39Z-
dc.date.issued2012-
dc.identifier.issn0939-5555-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89505-
dc.description.abstractWe investigated treatment outcomes of radiotherapy for solitary plasmacytoma (SP) and prognostic factors affecting survival. Between 1996 and 2010, a total of 38 patients were treated with radiotherapy for histologically proven plasmacytoma without evidence of multiple myeloma. Among these, 16 and 22 patients had SP originating from extramedullary soft tissue (EMP) and bone, respectively. Thirteen patients received adjuvant chemotherapy, and three patients underwent surgery prior to radiotherapy. At a median follow-up of 50 months (range, 8-142), radiotherapy demonstrated excellent local control (5- and 10-year local control rates, 81%). However, the 10-year multiple myeloma-free survival (MMFS) was 54% and the 10-year overall survival (OS) rates was 35%. Solitary bone plasmacytoma (SBP) more frequently progressed to multiple myeloma (MM) than EMP (10-year MMFS, 0% vs. 71%, p = 0.02). Radiotherapy with doses ≥40 Gy demonstrated better local control (10-year LC, 100% vs. 60%, p = 0.04) in SBP. In the multivariate analysis, elevated β₂-microglobulin was a significantly unfavorable prognostic factor affecting OS (p = 0.03). In conclusion, radiotherapy effectively treated SP without significant toxicity. However, progression to MM presents a challenging problem. Novel therapeutics are needed for patients with unfavorable prognostic factors.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfANNALS OF HEMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAntineoplastic Agents/therapeutic use-
dc.subject.MESHBiomarkers, Tumor/blood-
dc.subject.MESHBone Neoplasms/blood-
dc.subject.MESHBone Neoplasms/diagnosis-
dc.subject.MESHBone Neoplasms/drug therapy-
dc.subject.MESHBone Neoplasms/radiotherapy*-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPlasmacytoma/blood-
dc.subject.MESHPlasmacytoma/diagnosis-
dc.subject.MESHPlasmacytoma/drug therapy-
dc.subject.MESHPlasmacytoma/radiotherapy*-
dc.subject.MESHPrognosis-
dc.subject.MESHRemission Induction-
dc.subject.MESHSoft Tissue Neoplasms/blood-
dc.subject.MESHSoft Tissue Neoplasms/diagnosis-
dc.subject.MESHSoft Tissue Neoplasms/drug therapy-
dc.subject.MESHSoft Tissue Neoplasms/radiotherapy*-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHYoung Adult-
dc.subject.MESHbeta 2-Microglobulin/blood-
dc.titleRadiotherapy for solitary plasmacytoma of bone and soft tissue: outcomes and prognostic factors-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorYang-Gun Suh-
dc.contributor.googleauthorChang-Ok Suh-
dc.contributor.googleauthorJin Seok Kim-
dc.contributor.googleauthorSoo-Jeong Kim-
dc.contributor.googleauthorHae Ok Pyun-
dc.contributor.googleauthorJaeho Cho-
dc.identifier.doi10.1007/s00277-012-1510-6-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00633-
dc.contributor.localIdA01017-
dc.contributor.localIdA01861-
dc.contributor.localIdA01891-
dc.contributor.localIdA01919-
dc.contributor.localIdA03901-
dc.relation.journalcodeJ00161-
dc.identifier.eissn1432-0584-
dc.identifier.pmid22752147-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00277-012-1510-6-
dc.subject.keywordPlasmacytoma-
dc.subject.keywordExtramedullary plasmacytoma-
dc.subject.keywordSolitary bone plasmacytoma-
dc.subject.keywordRadiotherapy-
dc.contributor.alternativeNameKim, Soo Jeong-
dc.contributor.alternativeNameKim, Jin Seok-
dc.contributor.alternativeNamePyun, Hae Ok-
dc.contributor.alternativeNameSuh, Yang Gun-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.alternativeNameCho, Jae Ho-
dc.contributor.affiliatedAuthorKim, Soo Jeong-
dc.contributor.affiliatedAuthorKim, Jin Seok-
dc.contributor.affiliatedAuthorPyun, Hae Ok-
dc.contributor.affiliatedAuthorSuh, Yang Gun-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.contributor.affiliatedAuthorCho, Jae Ho-
dc.citation.volume91-
dc.citation.number11-
dc.citation.startPage1785-
dc.citation.endPage1793-
dc.identifier.bibliographicCitationANNALS OF HEMATOLOGY, Vol.91(11) : 1785-1793, 2012-
dc.identifier.rimsid31814-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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