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Usefulness of Enzyme-linked Immunosorbent Assay Using Recombinant BP180 and BP230 for Serodiagnosis and Monitoring Disease Activity of Bullous Pemphigoid

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dc.contributor.author김수찬-
dc.contributor.author김신영-
dc.contributor.author김송이-
dc.date.accessioned2014-12-19T16:25:24Z-
dc.date.available2014-12-19T16:25:24Z-
dc.date.issued2012-
dc.identifier.issn1013-9087-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/89497-
dc.description.abstractBACKGROUND: Bullous pemphigoid (BP) is an autoimmune subepidermal bullous disease associated with autoantibodies against BP180 and BP230. Enzyme-linked immunosorbent assay (ELISA) is a sensitive tool for the detection of immunoglobulin G (IgG) anti-BP180 and anti-BP230 autoantibodies. OBJECTIVE: The aim of this study was to evaluate the usefulness of ELISA for diagnosing and monitoring the disease activity of BP. METHODS: We evaluated serum IgG levels of anti-BP180 and anti-BP230 autoantibodies in 47 BP patients, 16 epidermolysis bullosa aquisita patients, and 15 healthy volunteers using ELISA. Through retrospective review of the medical records, the clinical characteristics of BP including disease activity, duration, pruritus severity and peripheral blood eosinophil counts were assessed. RESULTS: The sensitivity of BP180 ELISA was 97.9%, BP230 ELISA 72.3%, and a combination of the two was 100%. The specificity of BP180 ELISA was 90.3%, BP230 ELISA 100%, and a combination of the two was 90.3%. BP180 ELISA scores showed strong associations with disease activity, pruritus severity, peripheral blood eosinophil counts, and disease duration, whereas BP230 ELISA scores did not. CONCLUSION: BP180 and BP230 ELISAs are highly sensitive methods for the diagnosis of BP, and BP180 ELISA, in particular, is a sensitive tool for monitoring the disease activity of BP.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfANNALS OF DERMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleUsefulness of Enzyme-linked Immunosorbent Assay Using Recombinant BP180 and BP230 for Serodiagnosis and Monitoring Disease Activity of Bullous Pemphigoid-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorEui Hyung Lee-
dc.contributor.googleauthorYeon Hee Kim-
dc.contributor.googleauthorSinyoung Kim-
dc.contributor.googleauthorSong-ee Kim-
dc.contributor.googleauthorSoo-Chan Kim-
dc.identifier.doi22363155-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00675-
dc.contributor.localIdA00627-
dc.contributor.localIdA00637-
dc.relation.journalcodeJ00158-
dc.identifier.eissn2005-3894-
dc.identifier.pmid22363155-
dc.subject.keywordBP180 protein-
dc.subject.keywordBP230 protein-
dc.subject.keywordBullous pemphigoid-
dc.subject.keywordEnzyme-linked immunosorbent assay-
dc.contributor.alternativeNameKim, Soo Chan-
dc.contributor.alternativeNameKim, Sin Young-
dc.contributor.alternativeNameKim, Song Ee-
dc.contributor.affiliatedAuthorKim, Sin Young-
dc.contributor.affiliatedAuthorKim, Song Ee-
dc.contributor.affiliatedAuthorKim, Soo Chan-
dc.citation.volume24-
dc.citation.number1-
dc.citation.startPage45-
dc.citation.endPage55-
dc.identifier.bibliographicCitationANNALS OF DERMATOLOGY, Vol.24(1) : 45-55, 2012-
dc.identifier.rimsid31808-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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