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Association between opioid receptor gene polymorphism and postoperative pain response in Koreans

 Woo Kyung Lee  ;  Jeong Rim Lee  ;  Dong-Woo Han  ;  Kwan Hyung Kim  ;  Seung Ho Choi 
 Anesthesia and Pain Medicine, Vol.7(4) : 343-347, 2012 
Journal Title
Anesthesia and Pain Medicine
Issue Date
Mechanical pain threshold ; Opioid receptor ; Pain ; Polymorphism
Background:The objective of this study was to investigate the association between A118G single nucleotide polymorphism (SNP) of human Ռ-opioid receptor (OPRM1) gene and the postoperative pain response in Korean patients undergoing thyroidectomy. Methods:Fifty two adult patients undergoing thyroidectomy were enrolled in this study. Their blood samples were genotyped for the A118G polymorphism. Pain intensity was assessed by a verbal numerical rating scale (VNRS) at postanesthesia care unit, postoperative 6, 24, and 48 hours. Mechanical pain threshold was assessed using electronic von Frey preoperatively and repeated at postoperative 24 and 48 hours on the forearm and periincisional regions. Results:Of the 50 patients, 23 patients were A118 homozygous (AA), 19 patients were heterozygous (AG), and 8 patients were 118G homozygous (GG). The VNRS score was higher in patients with GG genotype than other genotypes at PACU (P < 0.05). Mechanical pain thresholds on the forearm and periincisional area were decreased at postoperative 24 and 48 hours from the preoperative values in all genotypes (P < 0.05). However, the changes in pain thresholds were similar among the genotypes. Conclusions:A118G SNP of OPRM1 gene is associated with inter-individual difference in immediate postoperative pain score in Korean population.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Kyung(이용경)
Lee, Jeong Rim(이정림) ORCID logo https://orcid.org/0000-0002-7425-0462
Choi, Seung Ho(최승호) ORCID logo https://orcid.org/0000-0001-8442-4406
Han, Dong Woo(한동우) ORCID logo https://orcid.org/0000-0002-8757-663X
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