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Intrahepatic cholangiocarcinoma with predominant "ductal plate malformation" pattern: a new subtype

Authors
 Yasuni Nakanuma  ;  Yasunori Sato  ;  Hiroko Ikeda  ;  Kenichi Harada  ;  Mikiko Kobayashi  ;  Kenji Sano  ;  Takeshi Uehara  ;  Masakazu Yamamoto  ;  Shunichi Ariizumi  ;  Young Nyun Park  ;  Joon Hyuk Choi  ;  Ensil Yu 
Citation
 AMERICAN JOURNAL OF SURGICAL PATHOLOGY, Vol.36(11) : 1629-1635, 2012 
Journal Title
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
ISSN
 0147-5185 
Issue Date
2012
MeSH
Aged ; Antigens, Neoplasm/metabolism ; Bile Duct Neoplasms/metabolism ; Bile Duct Neoplasms/pathology* ; Bile Ducts, Intrahepatic/metabolism ; Bile Ducts, Intrahepatic/pathology* ; Biomarkers, Tumor ; Cell Adhesion Molecules/metabolism ; Cholangiocarcinoma/complications ; Cholangiocarcinoma/metabolism ; Cholangiocarcinoma/pathology* ; Chronic Disease ; Epithelial Cell Adhesion Molecule ; Fatty Liver/complications ; Fatty Liver/pathology ; Female ; Humans ; Keratin-19/metabolism ; Ki-67 Antigen/metabolism ; Liver Diseases/complications ; Liver Diseases/pathology ; Male ; Mucin-1/metabolism
Keywords
Aged ; Antigens, Neoplasm/metabolism ; Bile Duct Neoplasms/metabolism ; Bile Duct Neoplasms/pathology* ; Bile Ducts, Intrahepatic/metabolism ; Bile Ducts, Intrahepatic/pathology* ; Biomarkers, Tumor ; Cell Adhesion Molecules/metabolism ; Cholangiocarcinoma/complications ; Cholangiocarcinoma/metabolism ; Cholangiocarcinoma/pathology* ; Chronic Disease ; Epithelial Cell Adhesion Molecule ; Fatty Liver/complications ; Fatty Liver/pathology ; Female ; Humans ; Keratin-19/metabolism ; Ki-67 Antigen/metabolism ; Liver Diseases/complications ; Liver Diseases/pathology ; Male ; Mucin-1/metabolism
Abstract
Ten cases of intrahepatic cholangiocarcinoma showing a highly differentiated adenocarcinoma mimicking ductal plate malformation (DPM) are reported. The patients included 7 males and 3 females with an average age of 69.5 years. Six cases were associated with chronic liver disease and the remaining 4 cases showed mild fatty change in the parenchyma and/or minimal to mild portal inflammation. Grossly, the tumor was a single nodule 1.5 to 6.6 cm in diameter, and was whitish and solid without a fibrous capsule. Microscopically, the tumor was composed of many vague, small nodular carcinomatous areas with desmoplastic reactions, and neoplastic glands had an irregularly dilated lumen lined with a single layer of cuboidal or low columnar carcinoma cells and irregular protrusions and bulges, resembling DPM. At its border, the carcinoma seemed to replace the non-neoplastic hepatic lobules or regenerative nodules. The central parts of the tumor were variably hypocellular and fibrotic. Although these carcinomas were negative for mucin and HepParI, they were frequently positive for CK19, epithelial cell adhesion molecule, and epithelial membrane antigen. Neural cell adhesion molecule was also expressed variably. The Ki-67 labeling index was <10% and p53 was scarcely expressed. In conclusion, a new subtype of intrahepatic cholangiocarcinoma with predominant DPM pattern was identified.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000478-201211000-00005&LSLINK=80&D=ovft
DOI
10.1097/PAS.0b013e31826e0249
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89462
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