Cited 0 times in
Involvement of human histamine N-methyltransferase gene polymorphisms in susceptibility to atopic dermatitis in Korean children.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경원 | - |
dc.contributor.author | 김규언 | - |
dc.contributor.author | 김미나 | - |
dc.contributor.author | 백지영 | - |
dc.contributor.author | 손명현 | - |
dc.contributor.author | 이경은 | - |
dc.contributor.author | 허원일 | - |
dc.contributor.author | 홍정연 | - |
dc.date.accessioned | 2014-12-19T16:22:08Z | - |
dc.date.available | 2014-12-19T16:22:08Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89396 | - |
dc.description.abstract | PURPOSE: Histamine N-methyltransferase (HNMT) catalyzes one of two major histamine metabolic pathways. Histamine is a mediator of pruritus in atopic dermatitis (AD). The aim of this study was to evaluate the association between HNMT polymorphisms and AD in children. METHODS: We genotyped 763 Korean children for allelic determinants at four polymorphic sites in the HNMT gene: -465T>C, -413C>T, 314C>T, and 939A>G. Genotyping was performed using a TaqMan fluorogenic 5' nuclease assay. The functional effect of the 939A>G polymorphism was analyzed. RESULTS: Of the 763 children, 520 had eczema and 542 had atopy. Distributions of the genotype and allele frequencies of the HNMT 314C>T polymorphism were significantly associated with non-atopic eczema (P=0.004), and those of HNMT 939A>G were significantly associated with eczema in the atopy groups (P=0.048). Frequency distributions of HNMT -465T>C and -413C>T were not associated with eczema. Subjects who were AA homozygous or AG heterozygous for 939A>G showed significantly higher immunoglobulin E levels than subjects who were GG homozygous (P=0.009). In U937 cells, the variant genotype reporter construct had significantly higher mRNA stability (P<0.001) and HNMT enzyme activity (P<0.001) than the common genotype. CONCLUSIONS: Polymorphisms in HNMT appear to confer susceptibility to AD in Korean children. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Involvement of human histamine N-methyltransferase gene polymorphisms in susceptibility to atopic dermatitis in Korean children. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Hee Seon Lee | - |
dc.contributor.googleauthor | Seung-Hyun Kim | - |
dc.contributor.googleauthor | Kyung Won Kim | - |
dc.contributor.googleauthor | Ji Young Baek | - |
dc.contributor.googleauthor | Hae-Sim Park | - |
dc.contributor.googleauthor | Kyung Eun Lee | - |
dc.contributor.googleauthor | Jung Yeon Hong | - |
dc.contributor.googleauthor | Mi Na Kim | - |
dc.contributor.googleauthor | Won Il Heo | - |
dc.contributor.googleauthor | Myung Hyun Sohn | - |
dc.contributor.googleauthor | Kyu-Earn Kim | - |
dc.identifier.doi | 22211168 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02651 | - |
dc.contributor.localId | A00303 | - |
dc.contributor.localId | A00327 | - |
dc.contributor.localId | A00441 | - |
dc.contributor.localId | A01838 | - |
dc.contributor.localId | A01967 | - |
dc.contributor.localId | A04361 | - |
dc.contributor.localId | A04431 | - |
dc.relation.journalcode | J00064 | - |
dc.identifier.eissn | 2092-7363 | - |
dc.identifier.pmid | 22211168 | - |
dc.subject.keyword | Atopic dermatitis | - |
dc.subject.keyword | children | - |
dc.subject.keyword | histamine, N-Methyltransferase | - |
dc.subject.keyword | polymorphism | - |
dc.contributor.alternativeName | Kim, Kyung Won | - |
dc.contributor.alternativeName | Kim, Kyu Earn | - |
dc.contributor.alternativeName | Kim, Mina | - |
dc.contributor.alternativeName | Baek, Ji Young | - |
dc.contributor.alternativeName | Son, Myung Hyun | - |
dc.contributor.alternativeName | Lee, Kyung Eun | - |
dc.contributor.alternativeName | Heo, Won Il | - |
dc.contributor.alternativeName | Hong, Jung Yeon | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Eun | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Won | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Earn | - |
dc.contributor.affiliatedAuthor | Kim, Mina | - |
dc.contributor.affiliatedAuthor | Baek, Ji Young | - |
dc.contributor.affiliatedAuthor | Son, Myung Hyun | - |
dc.contributor.affiliatedAuthor | Heo, Won Il | - |
dc.contributor.affiliatedAuthor | Hong, Jung Yeon | - |
dc.citation.volume | 4 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 31 | - |
dc.citation.endPage | 36 | - |
dc.identifier.bibliographicCitation | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, Vol.4(1) : 31-36, 2012 | - |
dc.identifier.rimsid | 34611 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.