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Clinical Implications of Non-A-Type NPM1 and FLT3 Mutations in Patients with Normal Karyotype Acute Myeloid Leukemia

Authors
 Park B.G.  ;  Chi H.-S.  ;  Park S.-J.  ;  Min S.K.  ;  Jang S.  ;  Park C.-J.  ;  Kim D.-Y.  ;  Lee J.-H.  ;  Lee J.-H.  ;  Lee K.-H. 
Citation
 ACTA HAEMATOLOGICA, Vol.127(2) : 63-71, 2012 
Journal Title
ACTA HAEMATOLOGICA
ISSN
 0001-5792 
Issue Date
2012
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Leukemia, Myeloid, Acute/genetics* ; Leukemia, Myeloid, Acute/mortality ; Male ; Middle Aged ; Mutation ; Nuclear Proteins/genetics* ; Prognosis ; Remission Induction ; Republic of Korea/epidemiology ; fms-Like Tyrosine Kinase 3/genetics*
Keywords
Acute myeloid leukemia ; FLT3 ; Nucleophosmin ; Prognosis
Abstract
Mutations in the nucleophosmin (NPM1) and fms-like tyrosine kinase-3 (FLT3) genes are the most commonly observed mutations in patients with normal-karyotype acute myeloid leukemia (AML-NK). We analyzed the prognostic effects and interactions of these mutations in 201 AML-NK patients. NPM1 and FLT3 mutations were found in 38.3 and 24.9% of AML-NK patients, respectively. NPM1 mutations (NPM1mut), especially in patients without FLT3 mutations (FLT3mut), were associated with a favorable outcome. However, NPM1mut did not affect survival. FLT3mut tended to be associated with a poor survival outcome. FLT3mut showed no prognostic effects in patients with A-type NPM1mut. However, FLT3mut were associated with a significantly worse prognosis in patients with non-A-type NPM1mut. The prognostic interaction between the NPM1 and FLT3 mutations was significant in patients with non-A-type NPM1mut.
Full Text
http://www.karger.com/Article/FullText/331509
DOI
22104247
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Park, Seo Jin(박서진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89363
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