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Insulin resistance is independently associated with peripheral and autonomic neuropathy in Korean type 2 diabetic patients

 Kee Ook Lee  ;  Ji Sun Nam  ;  Chul Woo Ahn  ;  Ji-Man Hong  ;  Seung-Min Kim  ;  Il-Nam Sunwoo  ;  Joon-Shik Moon  ;  Sang-Jun Na  ;  Young-Chul Choi 
 ACTA DIABETOLOGICA, Vol.49(2) : 97-103, 2012 
Journal Title
Issue Date
Adult ; Aged ; Autonomic Nervous System Diseases/etiology ; Autonomic Nervous System Diseases/metabolism ; Diabetes Mellitus, Type 2/complications* ; Diabetes Mellitus, Type 2/metabolism ; Diabetic Neuropathies/etiology* ; Diabetic Neuropathies/metabolism ; Female ; Humans ; Insulin Resistance* ; Male ; Middle Aged ; Republic of Korea ; Young Adult
Insulin resistance ; Autonomic neuropathy ; Peripheral neuropathy ; Type 2 diabetes mellitus
In addition to chronic hyperglycemia, insulin resistance itself has been proposed to cause a diabetic neuropathy. We evaluated the role of insulin resistance in the pathogenesis of peripheral and autonomic neuropathy in patients with type 2 diabetes. Eighty-six patients with type 2 diabetes were evaluated for the anthropometric and biochemical profiles, and Kitt value was calculated from insulin tolerance test to assess the insulin resistance. Various autonomic function tests, nerve conduction velocity, and quantitative sensory tests were performed to assess autonomic and peripheral neuropathy. In univariate analysis, both autonomic and peripheral neuropathy were significantly associated with glycemic exposure index (GE index), HDL-cholesterol, duration of DM, and Kitt value. In stepwise linear regression analysis, GE index was an independent predictor of autonomic and peripheral neuropathy (β = 0.643, P < 0.001; β = 0.207, P = 0.013, respectively), and Kitt value was also an independent factor for the autonomic and peripheral neuropathy (β = - 0.306, P < 0.001; β = - 0.329, P < 0.001, respectively). Low HDL-cholesterol increased the odds ratio for peripheral neuropathy. Insulin resistance is independently associated with peripheral and autonomic neuropathy in Korean Type 2 diabetic patients along with hyperglycemia and HDL-cholesterol.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Min(김승민) ORCID logo https://orcid.org/0000-0002-4384-9640
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Sunwoo, Il Nam(선우일남)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Choi, Young Chul(최영철) ORCID logo https://orcid.org/0000-0001-5525-6861
Hong, Ji Man(홍지만) ORCID logo https://orcid.org/0000-0002-0696-8448
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