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Progressive muscle relaxation therapy for atopic dermatitis: objective assessment of efficacy

 Byung Gi Bae  ;  Sang Ho Oh  ;  Chang Ook Park  ;  Seongmin Noh  ;  Ji Yeon Noh  ;  Kyung Ran Kim  ;  Kwang Hoon Lee 
 ACTA DERMATO-VENEREOLOGICA, Vol.92(1) : 57-61, 2012 
Journal Title
Issue Date
Adolescent ; Adult ; Anxiety/blood* ; Anxiety/complications ; Anxiety/therapy* ; Child ; Dermatitis, Atopic/blood* ; Dermatitis, Atopic/complications ; Dermatitis, Atopic/therapy* ; Female ; Humans ; Interleukin-13/blood ; Interleukin-4/blood ; Interleukin-5/blood ; Male ; Muscle Relaxation* ; Nerve Growth Factor/blood ; Neuropeptide Y/blood ; Pruritus/complications ; Pruritus/psychology ; Relaxation Therapy/methods* ; Severity of Illness Index ; Sleep Wake Disorders/complications ; Sleep Wake Disorders/psychology ; Statistics, Nonparametric ; Surveys and Questionnaires ; Treatment Outcome ; Young Adult
anxiety ; atopic dermatitis ; neuropeptide Y ; nerve growth factor ; progressive muscle relaxation
The aims of this study were to validate the efficacy of progressive muscle relaxation (PMR) in patients with atopic dermatitis and to evaluate the serological parameters that may serve as objective measures of the efficacy of PMR. A total of 25 patients with atopic dermatitis were randomly assigned to either a PMR group (n = 15) or a control group (n = 10). Serum levels of nerve growth, neuropeptide Y, and Th2 cytokines (IL-4, IL-5, and IL-13) were measured at baseline and after one month. At baseline, only anxiety was positively correlated with pruritus score (state anxiety: R = 0.496, p = 0.014; trait anxiety: R = 0.423, p = 0.04). Serum levels of neuropeptide Y were inversely related to the State-Trait Anxiety Inventory (STAI) (state anxiety: R = -0.475, p = 0.019; trait anxiety: R = -0.418, p = 0.042) and pruritus scores (R = -0.451, p = 0.035). After one month of PMR therapy, the degree of pruritus and loss of sleep was significantly decreased in the PMR group (p < 0.001), but not among controls. State anxiety scores showed significant improvement after treatment only in the PMR group (p = 0.005). There were no significant changes in the serological parameters in either group. Reductions in Eczema Area and Severity Index (EASI) scores were significant, but similar, in both groups. PMR may be a useful adjunctive modality for the management of atopic dermatitis through the reduction of anxiety. No change was found in biological parameters, but it was observed that neuropeptide Y may be related to high levels of anxiety in atopic dermatitis at baseline.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Ran(김경란) ORCID logo https://orcid.org/0000-0001-8375-1851
Park, Chang Ook(박창욱) ORCID logo https://orcid.org/0000-0003-3856-1201
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
Lee, Kwang Hoon(이광훈)
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