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Synchronous development of intrahepatic cholangiocarcinoma and hepatocellular carcinoma in different sites of the liver with chronic B-viral hepatitis: two case reports

 Kyu Sik Jung  ;  Kyeong Hyeon Chun  ;  Gi Hong Choi  ;  Hyae Min Jeon  ;  Hye Sun Shin  ;  Young Nyun Park  ;  Jun Yong Park 
 BMC Research Notes, Vol.6 : 520, 2013 
Journal Title
 BMC Research Notes 
Issue Date
Aged ; Cholangiocarcinoma/complications* ; Chronic Disease ; Female ; Hepatitis B/complications* ; Humans ; Liver Neoplasms/complications*
Hepatocellular carcinoma ; Intrahepatic cholangiocarcinoma ; Double primary liver cancer ; Hepatitis B virus ; Chronic liver disease
BACKGROUND: Synchronous development of primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma has been reported rarely. In literature review, there have been only 35 reported cases of synchronous hepatocellular carcinoma and intrahepatic cholangiocarcinoma, and most of these tumors developed in patients with hepatitis C-related liver cirrhosis. Here, we present synchronous development of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in two patients with chronic B-viral hepatitis. CASE PRESENTATION: Two patients with chronic hepatitis B were referred to our hospital due to a hepatic mass. Patient 1 had a 6.4 cm multinodular hepatic mass in the left lobe and a small nodule in the right lobe. Patient 2 had a 4.3 cm hypervascular mass in the right lobe and a 1.1 cm nodule in the left lobe. The pre-operative diagnosis of both cases was hepatocellular carcinoma with metastatic nodule, however, surgical resection pathology revealed that hepatocellular carcinoma and intrahepatic cholangiocarcinoma existed independently in the other side of the liver in both cases. Additionally, the background liver histology of both cases was hepatitis B-related chronic hepatitis without cirrhotic change. CONCLUSION: Our cases suggest that hepatitis B virus infection can also predispose to development of double liver cancers.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Shin, Hye Sun(신혜선)
Chun, Kyeong Hyeon(전경현) ORCID logo https://orcid.org/0000-0002-7798-658X
Jeon, Hyae Min(전혜민)
Jung, Kyu Sik(정규식)
Choi, Gi Hong(최기홍) ORCID logo https://orcid.org/0000-0002-1593-3773
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