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Complete mitochondrial genome of Haplorchis talchui and comparative anlaysis with other trematodes

Authors
 Dongmin Lee  ;  Seongjun Choe  ;  Hansol Park  ;  Hyeong-Kyu Jeon  ;  Jong-Yil Chai  ;  Woon-Mok Sohn  ;  Tai-Soon Yong  ;  Duk-Young Min  ;  Han-Jong Rim  ;  Keeseon S. Eom 
Citation
 KOREAN JOURNAL OF PARASITOLOGY, Vol.51(6) : 719-726, 2013 
Journal Title
 KOREAN JOURNAL OF PARASITOLOGY 
ISSN
 0023-4001 
Issue Date
2013
MeSH
Animals ; Asia ; Codon, Initiator ; DNA, Mitochondrial/chemistry ; DNA, Mitochondrial/genetics ; Gene Order ; Genes, Helminth ; Genome, Mitochondrial* ; Heterophyidae/genetics* ; Heterophyidae/isolation & purification ; Humans ; Molecular Sequence Data ; Sequence Analysis, DNA
Keywords
Haplorchis taichui ; mitochondrial genome ; molecular phylogeny ; trematode
Abstract
Mitochondrial genomes have been extensively studied for phylogenetic purposes and to investigate intra- and interspecific genetic variations. In recent years, numerous groups have undertaken sequencing of platyhelminth mitochondrial genomes. Haplorchis taichui (family Heterophyidae) is a trematode that infects humans and animals mainly in Asia, including the Mekong River basin. We sequenced and determined the organization of the complete mitochondrial genome of H. taichui. The mitochondrial genome is 15,130 bp long, containing 12 protein-coding genes, 2 ribosomal RNAs (rRNAs, a small and a large subunit), and 22 transfer RNAs (tRNAs). Like other trematodes, it does not encode the atp8 gene. All genes are transcribed from the same strand. The ATG initiation codon is used for 9 protein-coding genes, and GTG for the remaining 3 (nad1, nad4, and nad5). The mitochondrial genome of H. taichui has a single long non-coding region between trnE and trnG. H. taichui has evolved as being more closely related to Opisthorchiidae than other trematode groups with maximal support in the phylogenetic analysis. Our results could provide a resource for the comparative mitochondrial genome analysis of trematodes, and may yield genetic markers for molecular epidemiological investigations into intestinal flukes.
Files in This Item:
T201305935.pdf Download
DOI
10.3347/kjp.2013.51.6.719
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
Yonsei Authors
Yong, Tai Soon(용태순) ORCID logo https://orcid.org/0000-0002-3445-0769
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89301
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