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Effects of SLC2A9 variants on uric acid levels in a Korean population

Authors
 Jae Woong Sull  ;  Eun Jung Park  ;  Myoungsook Lee  ;  Sun Ha Jee 
Citation
 RHEUMATOLOGY INTERNATIONAL, Vol.33(1) : 19-23, 2013 
Journal Title
 RHEUMATOLOGY INTERNATIONAL 
ISSN
 0172-8172 
Issue Date
2013
MeSH
Adult ; Chromosomes, Human, Pair 4 ; Cohort Studies ; Female ; Genetic Predisposition to Disease* ; Genome-Wide Association Study* ; Glucose Transport Proteins, Facilitative/genetics* ; Humans ; Hyperuricemia/blood ; Hyperuricemia/ethnology ; Hyperuricemia/genetics* ; Male ; Meta-Analysis as Topic ; Polymorphism, Single Nucleotide* ; Uric Acid/blood*
Keywords
SLC2A9 ; Polymorphisms ; Uric acid ; Korean
Abstract
Elevated uric acid levels are associated with a variety of adverse health risks. Genome-wide association studies have identified several candidate genes associated with serum uric acid levels, including SLC2A9. We carried out a replication study of SLC2A9 variants in two Korean cohorts. A total of 961 participants in Seoul City were genotyped using a genome-wide marker panel, and 1,859 participants in the Bundang-Gu area were used for a replication study with a selected marker. Multivariate linear regression models were employed to test for genotypic effects on uric acid levels while adjusting for age, sex, and smoking status using an additive model. The top single nucleotide polymorphism associated with uric acid levels was rs4529048 in the SLC2A9 gene on chromosome 4 (P = 2.12 × 10−6 in the Seoul City sample; P = 1.55 × 10−9 in the Bundang-Gu sample). The meta-analysis P value for rs4529048 in the combined 2,820 individuals was 1.17 × 10−14. This study demonstrates that genetic variants in SLC2A9 influence uric acid levels in Korean adults.
Full Text
http://link.springer.com/article/10.1007%2Fs00296-011-2303-2
DOI
10.1007/s00296-011-2303-2
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89263
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