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Immunopathogenic Role of Herpes Simplex Virus in Behçet’s Disease

Authors
 Do Young Kim  ;  Suhyun Cho  ;  Min Ju Choi  ;  Seonghyang Sohn  ;  Eun-So Lee  ;  Dongsik Bang 
Citation
 Genetics Research International, Vol.2013 : 638273, 2013 
Journal Title
 Genetics Research International 
ISSN
 2090-3154 
Issue Date
2013
Abstract
The role of viral infections, such as herpes simplex virus (HSV) infection, in the pathogenesis of Behçet’s disease (BD) has been investigated for many years. HSV has been detected in peripheral blood leukocytes, saliva, and genital ulcers of patients with BD. Various cell adhesion molecules on cultured endothelial cells have been induced by HSV in a TNF-α dependent manner. In addition, a BD-like animal model was developed by inoculating ICR mouse earlobes with HSV, and antiviral treatment was effective in improving BD-like symptoms in this model. Still, there are several incompletely characterized proteins that possess antiviral properties and are being investigated as mediators of viral infection-related chronic inflammatory reactions. Although the role of HSV in the pathogenesis of BD remains to be fully established, recent research findings regarding HSV in BD have expanded our understanding of the disease and will hopefully lead to the development of more effective therapeutic agents in the near future.
Files in This Item:
T201305817.pdf Download
DOI
10.1155/2013/638273
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영) ORCID logo https://orcid.org/0000-0002-0194-9854
Bang, Dong Sik(방동식)
Cho, Su Hyun(조수현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89245
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