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Impact of Atopy on Asthma and Allergic Rhinitis in the Cohort for Reality and Evolution of Adult Asthma in Korea

Authors
 An-Soo Jang  ;  Sang-Heon Kim  ;  Tae-Bum Kim  ;  Heung-Woo Park  ;  Sae-Hoon Kim  ;  Yoon-Seok Chang  ;  Jae Hyun Lee  ;  You Sook Cho  ;  Jung Won Park  ;  Dong-Ho Nahm  ;  Young-Joo Cho  ;  Sang-Heon Cho  ;  Ho Joo Yoon  ;  Byoung-Whui Choi  ;  Hee-Bom Moon  ;  Choon-Sik Park 
Citation
 ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, Vol.5(3) : 143-149, 2013 
Journal Title
 ALLERGY ASTHMA & IMMUNOLOGY RESEARCH 
ISSN
 2092-7355 
Issue Date
2013
Keywords
Asthma ; allergens ; allergic rhinitis
Abstract
PURPOSE: Atopy is an important cause of asthma. Few data on the prevalence of atopy or comparisons with clinical characteristics of asthma in Korean patients have been published. We evaluated the effects of atopy on clinical profiles and airway inflammation in Korean asthmatics. METHODS: We retrospectively enrolled 1,492 asthmatics from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA) cohort who had undergone skin prick tests for aeroallergens. The patients' clinical characteristics, lung function, PC20, and sputum and blood inflammatory cell counts were compared based on the presence or absence of atopy. Atopy was defined as one or more positive reactions (A/H ratio >1) on a skin prick test. RESULTS: Among 11 aeroallergens, house dust mites (Dermatophagoides farinae and Dermatophagoides pteronyssinus) were the most prevalent cause of a positive skin prick test. As compared with non-atopic asthmatics, atopic asthmatics showed early onset of the disease. Atopic patients with asthma had a higher FEV1, FVC, and FEV1/FVC as compared with non-atopic patients with asthma. In addition, asthmatics without atopy had more uncontrolled asthma (P=0.001) and severe rhinitis (P<0.05) as compared with atopic asthmatics. Smoking, as measured in pack years, was higher in the non-atopic asthmatics than in the atopic asthmatics. The erythrocyte sedimentation rate was higher in non-atopic asthmatics than in the atopic asthmatics and patients with non-atopic asthma had a higher sputum neutrophil count than did those with atopic asthma. CONCLUSIONS: Our data indicate that atopic asthmatics had an early onset of disease and high IgE levels, while the non-atopic asthmatics had decreased lung function and a high sputum neutrophil count, suggesting that a different approach is needed to treat atopic asthma.
Files in This Item:
T201305805.pdf Download
DOI
10.4168/aair.2013.5.3.143
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Lee, Jae Hyun(이재현) ORCID logo https://orcid.org/0000-0002-0760-0071
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89235
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