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The Urate-lowering Efficacy and Safety of Febuxostat in Korean Patients with Gout

 Sung Hwan Park  ;  Yeong Wook Song  ;  Won Park  ;  Eun Mi Koh  ;  Bin Yoo  ;  Soo Kon Lee  ;  Dae Hyun Yoo  ;  Yun Jong Lee  ;  Hyun Ah Kim  ;  Hyo Jin Choi  ;  Ho Youn Kim  ;  Hyong Gi Jung 
 Journal of Rheumatic Diseases, Vol.20(4) : 223-230, 2013 
Journal Title
 Journal of Rheumatic Diseases 
Issue Date
Gout ; Febuxostat ; Urate-lowering efficacy ; Korean patients
Objective: To compare the urate-lowering efficacy and the safety of febuxostat, allopurinol and placebo in Korean patients with gout for 4 weeks. Methods: Subjects (n=182) with gout were randomized to febuxostat (40, 80, 120 mg), allopurinol 300 mg, or placebo group. The primary end point was the proportion of subjects whose serum urate concentration fell to less than 6.0 mg/dL after the 4-week treatment. Results: The primary end point was reached at 25.7%, 80.0% and 83.3% of patients receiving 40, 80 and 120 mg of febuxostat, respectively, 58.3% of those receiving 300 mg of allopurinol and none of the placebo (p<0.001: each febuxostat dose or allopurinol group versus placebo group, p=0.0484 and p=0.0196: febuxostat 80 and 120 mg compared with allopurinol, respectively). The number and proportion of subjects who developed adverse events (AEs) were 13 subjects (37%), 14 (39%) and 18 (50%) in the febuxostat of 40, 80 and 120 mg group, respectively, 21 (57%) in the allopurinol 300 mg group and 17 (46%) in the placebo group. No statistically significant differences in the incidence rates of adverse events were observed between the groups. There was no significant difference in gout flare-up incidence. Conclusion: Febuxostat, 80 mg or 120 mg, was more effective than allopurinol (300 mg) or placebo, when lowering the serum urate. The safety of febuxostat and allopurinol was comparable.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Soo Kon(이수곤)
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