Cited 12 times in
Enhanced random skin flap survival by sustained delivery of fibroblast growth factor 2 in rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이세형 | - |
dc.date.accessioned | 2014-12-18T09:57:46Z | - |
dc.date.available | 2014-12-18T09:57:46Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1445-1433 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89159 | - |
dc.description.abstract | BACKGROUND: Skin flap survival is a major challenge in reconstructive plastic surgery. Here, we examined the effect of sustained delivery of fibroblast growth factor 2 (FGF2) using heparin-conjugated fibrin (HCF) on skin flap survival in rats. METHODS: Rats with a skin flap received either phosphate-buffered saline/FGF2 or HCF/FGF2 in the recipient bed. For the no-treatment group, a random skin flap was sutured on the back without any treatment. Seven days after surgery, angiogenesis in the skin flap was evaluated by using Visitrak system and conventional healing quality scoring method. The efficacy of HCF/FGF2 in skin flap survival was evaluated by comparing the results from different groups. RESULTS: The necrotic area of the skin flap significantly decreased in the HCF/FGF2 group as compared with the other groups. CONCLUSION: The sustained delivery of FGF2 using HCF has a therapeutic potential to improve skin flap survival. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ANZ JOURNAL OF SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Angiogenesis Inducing Agents/administration & dosage* | - |
dc.subject.MESH | Angiogenesis Inducing Agents/pharmacology | - |
dc.subject.MESH | Angiogenesis Inducing Agents/therapeutic use | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anticoagulants/administration & dosage | - |
dc.subject.MESH | Delayed-Action Preparations | - |
dc.subject.MESH | Fibrinogen/administration & dosage | - |
dc.subject.MESH | Fibroblast Growth Factor 2/administration & dosage* | - |
dc.subject.MESH | Fibroblast Growth Factor 2/pharmacology | - |
dc.subject.MESH | Fibroblast Growth Factor 2/therapeutic use | - |
dc.subject.MESH | Heparin/administration & dosage | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Necrosis/etiology | - |
dc.subject.MESH | Necrosis/prevention & control | - |
dc.subject.MESH | Neovascularization, Physiologic/drug effects* | - |
dc.subject.MESH | Postoperative Complications/prevention & control | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Surgical Flaps*/blood supply | - |
dc.subject.MESH | Surgical Flaps*/pathology | - |
dc.subject.MESH | Surgical Flaps*/physiology | - |
dc.subject.MESH | Wound Healing/drug effects* | - |
dc.title | Enhanced random skin flap survival by sustained delivery of fibroblast growth factor 2 in rats | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Research Institute for Cerebral & Cardiovascular Diseases (심혈관제품유효성평가센터) | - |
dc.contributor.googleauthor | Hyoung Joon Park | - |
dc.contributor.googleauthor | Seahyoung Lee | - |
dc.contributor.googleauthor | Kyo Hwa Kang | - |
dc.contributor.googleauthor | Chan Yeong Heo | - |
dc.contributor.googleauthor | Ji Hoon Kim | - |
dc.contributor.googleauthor | Hee Seok Yang | - |
dc.contributor.googleauthor | Byung-Soo Kim | - |
dc.identifier.doi | 10.1111/j.1445-2197.2012.06194.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02883 | - |
dc.relation.journalcode | J00193 | - |
dc.identifier.eissn | 1445-2197 | - |
dc.identifier.pmid | 22943384 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1445-2197.2012.06194.x/abstract | - |
dc.subject.keyword | fibroblast growth factor 2 | - |
dc.subject.keyword | heparin‐conjugated fibrin | - |
dc.subject.keyword | skin flap survival | - |
dc.subject.keyword | sustained delivery | - |
dc.contributor.alternativeName | Lee, Sea Hyoung | - |
dc.contributor.affiliatedAuthor | Lee, Sea Hyoung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 83 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 354 | - |
dc.citation.endPage | 358 | - |
dc.identifier.bibliographicCitation | ANZ JOURNAL OF SURGERY, Vol.83(5) : 354-358, 2013 | - |
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