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Clinical outcomes for rectal carcinoid tumors according to a new (AJCC 7th edition) TNM staging system: a single institutional analysis of 122 patients

Authors
 Min Sung Kim  ;  Hyuk Hur  ;  Byung Soh Min  ;  Seung Hyuk Baik  ;  Kang Young Lee  ;  Nam Kyu Kim 
Citation
 JOURNAL OF SURGICAL ONCOLOGY, Vol.107(8) : 835-841, 2013 
Journal Title
JOURNAL OF SURGICAL ONCOLOGY
ISSN
 0022-4790 
Issue Date
2013
MeSH
Adult ; Aged ; Aged, 80 and over ; Carcinoid Tumor/mortality ; Carcinoid Tumor/pathology* ; Carcinoid Tumor/therapy ; Disease-Free Survival ; Female ; Humans ; Lymph Nodes/pathology* ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Staging ; Predictive Value of Tests ; Prognosis ; Rectal Neoplasms/mortality ; Rectal Neoplasms/pathology* ; Rectal Neoplasms/therapy ; Retrospective Studies ; Risk Factors ; Treatment Outcome ; United States
Keywords
Adult ; Aged ; Aged, 80 and over ; Carcinoid Tumor/mortality ; Carcinoid Tumor/pathology* ; Carcinoid Tumor/therapy ; Disease-Free Survival ; Female ; Humans ; Lymph Nodes/pathology* ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Staging ; Predictive Value of Tests ; Prognosis ; Rectal Neoplasms/mortality ; Rectal Neoplasms/pathology* ; Rectal Neoplasms/therapy ; Retrospective Studies ; Risk Factors ; Treatment Outcome ; United States
Abstract
BACKGROUND AND OBJECTIVES:
This study aimed to describe clinical outcomes of rectal carcinoids according to the 7th American Joint Council on Cancer (AJCC) TNM staging system.
METHODS:
We retrospectively reviewed 122 patients who were treated for rectal carcinoids between 1995 and 2010.
RESULTS:
Among 122 patients, 81.2% (n = 99) were classified as stage I, 4.9% (n = 6) as stage II, 11.5% (n = 14) as stage III, and 2.5% (n = 3) as stage IV. Lymph node (LN) metastasis rates for pT1a, 1b, 2, and 3 stages were 1.2% (1/85), 16.7% (3/18), 0% (0/4) and 84.6% (11/13), respectively. The 5-year overall survival (OS) rate was 88.4%. The 5-year OS rates were estimated to be 100%, 80%, 51.4% and 0% for stage I, II, III, and IV, respectively (P < 0.001). The 5-year disease-free survival (DFS) rate was 82.3%. The 5-year DFS rates were estimated to be 97.7%, 62.5%, 17.1%, and 0% for stages I, II, III, and IV, respectively (P < 0.001).
CONCLUSIONS:
Using the new TNM stage, we confirmed a prognostic difference in LN metastasis rates, OS, and DFS for rectal carcinoids. In clinical practice, the new TNM stage can be very useful for predicting prognosis.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jso.23327/abstract
DOI
10.1002/jso.23327
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Min Sung(김민성)
Min, Byung Soh(민병소) ORCID logo https://orcid.org/0000-0003-0180-8565
Baik, Seung Hyuk(백승혁) ORCID logo https://orcid.org/0000-0003-4183-2332
Lee, Kang Young(이강영)
Hur, Hyuk(허혁) ORCID logo https://orcid.org/0000-0002-9864-7229
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89152
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