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Intestinal Behcet's disease appearing during treatment with adalimumab in a patient with ankylosing spondylitis.

Authors
 Sook Hee Chung  ;  Soo Jung Park  ;  Sung Pil Hong  ;  Jae Hee Cheon  ;  Tae Il Kim  ;  Won Ho Kim 
Citation
 WORLD JOURNAL OF GASTROENTEROLOGY, Vol.19(32) : 5389-5392, 2013 
Journal Title
 WORLD JOURNAL OF GASTROENTEROLOGY 
ISSN
 1007-9327 
Issue Date
2013
MeSH
Adalimumab ; Adult ; Anti-Inflammatory Agents/therapeutic use* ; Antibodies, Monoclonal, Humanized/therapeutic use* ; Azathioprine/therapeutic use ; Behcet Syndrome/diagnosis* ; Behcet Syndrome/drug therapy ; Colonoscopy ; Drug Therapy, Combination ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Intestinal Diseases/diagnosis* ; Intestinal Diseases/drug therapy ; Male ; Middle Aged ; Remission Induction ; Spondylitis, Ankylosing/diagnosis ; Spondylitis, Ankylosing/drug therapy* ; Steroids/therapeutic use ; Tomography, X-Ray Computed ; Treatment Outcome
Keywords
Adalimumab ; Intestinal Behçet’s disease ; Tumor necrosis factor-α
Abstract
Behçet’s disease (BD) is a chronic inflammatory disease affecting multiple organ systems, such as the skin, joints, blood vessels, central nervous system, and gastrointestinal tract. Intestinal BD is characterized by intestinal ulcerations and gastrointestinal symptoms. The medical treatment of intestinal BD includes corticosteroids and immunosupressants. There have been several reports of tumor necrosis factor-α (TNF-α) blockers being successful in treatment of refractory intestinal BD. Here, we report on a patient who was diagnosed with intestinal BD despite treatment with the fully humanized TNF-α blocker (adalimumab) for underlying ankylosing spondylitis. This patient achieved clinical remission and complete mucosal healing through the addition of a steroid and azathioprine to the adalimumab regimen.
Files in This Item:
T201305634.pdf Download
DOI
10.3748/wjg.v19.i32.5389
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Park, Soo Jung(박수정)
Chung, Sook Hee(정숙희)
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
Hong, Sung Pil(홍성필)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89133
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