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Effect of the prosthesis–patient mismatch on long-term clinical outcomes after isolated aortic valve replacement for aortic stenosis: A prospective observational study

Authors
 Soonchang Hong  ;  Gijong Yi  ;  Young-Nam Youn  ;  Sak Lee  ;  Kyung-Jong Yoo  ;  Byung-Chul Chang 
Citation
 JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Vol.146(5) : 1098-1104, 2013 
Journal Title
 JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 
ISSN
 0022-5223 
Issue Date
2013
MeSH
Aged ; Aortic Valve Stenosis/mortality ; Aortic Valve Stenosis/physiopathology ; Aortic Valve Stenosis/surgery* ; Chi-Square Distribution ; Disease-Free Survival ; Female ; Heart Valve Prosthesis* ; Heart Valve Prosthesis Implantation/adverse effects ; Heart Valve Prosthesis Implantation/instrumentation* ; Heart Valve Prosthesis Implantation/mortality ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Multivariate Analysis ; Proportional Hazards Models ; Prospective Studies ; Prosthesis Design ; Republic of Korea ; Risk Factors ; Time Factors ; Treatment Outcome ; Ventricular Remodeling
Keywords
17 ; 35.2 ; 35.3 ; 36.2 ; AS ; AVR ; EOA ; LVMI ; LVOT ; PPM ; aortic stenosis ; aortic valve replacement ; effective orifice area ; left ventricular mass index ; left ventricular outflow tract ; prosthesis–patient mismatch
Abstract
BACKGROUND: The effect of prosthesis-patient mismatch (PPM) on clinical outcomes after aortic valve replacement remains controversial. We evaluated effect of PPM on long-term clinical outcomes after isolated aortic valve replacement in patients with predominant aortic stenosis. METHODS: We analyzed data from patients with predominant aortic stenosis who underwent isolated aortic valve replacement between January 1995 and July 2010. The indexed effective orifice area, obtained by dividing the in vivo effective orifice area by the patient's body surface area, was used to define PPM as clinically nonsignificant (group I, 224 patients), mild (group II, 52 patients), moderate (group III, 39 patients), and severe (group IV, 36 patients). RESULTS: Early survival was not significantly different among the groups, but overall survival was decreased gradually in group IV. Overall survival at 12 years was lower in group IV than in group I (92.8% ± 2.7% vs 67.0 ± 10.1, respectively; P = .001). Cardiac-related-death-free survival at 12 years was lower in patients with severe PPM. Left ventricular mass index decreased during the follow-up period in all groups. But left ventricular mass index was less decreased in group IV compared with groups I, II, and III. Age, severe PPM, and ejection fraction <40%, and New York Heart Association Functional Class IV were independent risk factors of overall survival on multivariate analysis. Severe PPM was an independent risk factor for cardiac-related death. CONCLUSIONS: Severe PPM showed an adverse effect on long-term survival, and was an independent risk factor for cardiac-related death. In addition, patients with severe PPM showed less decreasing left ventricular mass index during follow-up.
Full Text
http://www.sciencedirect.com/science/article/pii/S0022522312009488
DOI
10.1016/j.jtcvs.2012.07.101
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Yoo, Kyung Jong(유경종) ORCID logo https://orcid.org/0000-0002-9858-140X
Youn, Young Nam(윤영남)
Yi, Gi Jong(이기종)
Lee, Sak(이삭) ORCID logo https://orcid.org/0000-0001-6130-2342
Chang, Byung Chul(장병철)
Hong, Soon Chang(홍순창)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89088
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