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Nine-Month Angiographic and Intravascular Ultrasound Outcomes After Resolute Zotarolimus-Eluting Stent Implantation for the Treatment of In-Stent Restenosis

Authors
 SEUNG-YUL LEE  ;  BYEONG-KEUK KIM  ;  JUNG-SUN KIM  ;  MYEONG-KI HONG  ;  DEOK-KYU CHO  ;  JUNGHAN YOON  ;  DONG WOON JEON  ;  NAM-HO LEE  ;  HYUCK MOON KWON  ;  YANGSOO JANG 
Citation
 JOURNAL OF INTERVENTIONAL CARDIOLOGY, Vol.26(6) : 543-549, 2013 
Journal Title
 JOURNAL OF INTERVENTIONAL CARDIOLOGY 
ISSN
 0896-4327 
Issue Date
2013
MeSH
Coronary Angiography* ; Coronary Restenosis/diagnosis* ; Coronary Restenosis/therapy* ; Drug-Eluting Stents* ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Sirolimus/administration & dosage ; Sirolimus/analogs & derivatives* ; Time Factors ; Treatment Outcome ; Ultrasonography, Interventional*
Keywords
Coronary Angiography* ; Coronary Restenosis/diagnosis* ; Coronary Restenosis/therapy* ; Drug-Eluting Stents* ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Sirolimus/administration & dosage ; Sirolimus/analogs & derivatives* ; Time Factors ; Treatment Outcome ; Ultrasonography, Interventional*
Abstract
OBJECTIVES: We aimed to evaluate the mid-term outcomes of resolute zotarolimus-eluting stent (R-ZES) implantation for in-stent restenosis (ISR). BACKGROUND: There has been a paucity of data regarding the effects of new-generation drug-eluting stent to treat ISR. METHODS: From 2009 to 2010, a total of 98 patients with 98 ISR lesions were prospectively enrolled after R-ZES implantation for the treatment of ISR. Among 98 patients, 73 patients underwent follow-up angiography at 9 months. Serial intravascular ultrasound (IVUS) at both postprocedure and 9 months was evaluated in 55 patients. The overlapped segment of R-ZES was defined as the portion of R-ZES superimposed on previous stent. RESULTS: Late loss and binary restenosis rate were 0.3 ± 0.5 mm and 5.5% at 9 months. On IVUS, the percentage of neointimal volume and maximum percentage of neointimal area were 3.9 ± 6.3% and 17.3 ± 15.5%, respectively. There was no significant change of vessel volume index between postprocedure and 9 months (16.9 ± 4.7 mm³ /mm vs. 17.1 ± 4.6 mm³ /mm, P = 0.251). Late-acquired incomplete stent apposition was observed in 5 (5/55, 9.1%) cases. Compared with nonoverlapped segments of R-ZES, the overlapped did not show larger neointimal volume index (0.3 ± 0.5 mm³ /mm vs. 0.2 ± 0.3 mm³ /mm, P = 0.187) on 9-month IVUS. During follow-up (median, 353 days), repeat target-lesion revascularization was performed in four cases, but there were no death or stent thrombosis. CONCLUSIONS: This study suggested that R-ZES implantation for the treatment of ISR was effective up to 9 months and showed favorable vascular responses on serial IVUS assessment.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/joic.12073/abstract
DOI
10.1111/joic.12073
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Kim, Byeong Keuk(김병극) ORCID logo https://orcid.org/0000-0003-2493-066X
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Lee, Seung Yul(이승율)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88990
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