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Response to antidepressants in major depressive disorder with melancholic features: the CRESCEND study.

Authors
 Su-Jin Yang  ;  Robert Stewart  ;  Hee-Ju Kang  ;  Seon-Young Kim  ;  Kyung-Yeol Bae  ;  Jae-Min Kim  ;  Sung-Won Jung  ;  Min-Soo Lee  ;  Hyeon-Woo Yim  ;  Tae-Youn Jun 
Citation
 JOURNAL OF AFFECTIVE DISORDERS, Vol.144(1-2) : 42-50, 2013 
Journal Title
JOURNAL OF AFFECTIVE DISORDERS
ISSN
 0165-0327 
Issue Date
2013
MeSH
Adult ; Antidepressive Agents/therapeutic use* ; Depressive Disorder/diagnosis* ; Depressive Disorder, Major/drug therapy* ; Depressive Disorder, Major/psychology ; Diagnostic and Statistical Manual of Mental Disorders ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Republic of Korea ; Serotonin Uptake Inhibitors/therapeutic use ; Treatment Outcome
Keywords
Depression ; Melancholia ; Antidepressants ; Response ; Korea
Abstract
BACKGROUND: This study aimed to determine whether major depressive disorders with melancholic and without melancholic features differ with respect to their responses to treatment with antidepressants.
METHODS: From a nationwide sample of 18 hospitals in South Korea, 559 presenting patients with major depressive disorder were recruited. The DSM-IV based Structured Clinical Interview was administered for confirmatory diagnoses and depression subtypes with/without melancholic features. After baseline evaluation, they received naturalistic clinician-determined antidepressant interventions. Assessment scales for evaluating depression (HAMD), anxiety (HAMA), global severity (CGI-s), and functioning (SOFAS) were administered at baseline and re-evaluated at 1, 2, 4, 8, and 12 weeks later.
RESULTS: At baseline, the 243 (43.5%) participants with melancholic features were more likely to have a previous history of depression, and had higher HAMA and lower SOFAS scores. After adjustment for baseline status, participants with melancholic features were more likely to achieve and to experience shorter times to CGI-s remission and associated with an enhanced global symptomatic remission with any antidepressant treatment. They were more likely to achieve and to experience shorter times to CGI-s remission and this difference was strongest in those receiving selective serotonin reuptake inhibitor (SSRI) antidepressants treatment.
LIMITATIONS: The study was observational, and the treatment modality was naturalistic.
CONCLUSIONS: These findings suggest a faster and more evident global response to pharmacotherapy in melancholia compared to other depressive syndromes, particularly where SSRI agents are used.
Full Text
http://www.sciencedirect.com/science/article/pii/S0165032712004442
DOI
10.1016/j.jad.2012.06.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Yang, Su-Jin(양수진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88963
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