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Elevated levels of serum tumor markers CA 15-3 and CEA are prognostic factors for diagnosis of metastatic breast cancers.

Authors
 Jun Sang Lee  ;  Seho Park  ;  Ji Min Park  ;  Jung Hoon Cho  ;  Seung Il Kim  ;  Byeong-Woo Park 
Citation
 Breast Cancer Research and Treatment, Vol.141(3) : 477-484, 2013 
Journal Title
 Breast Cancer Research and Treatment 
ISSN
 0167-6806 
Issue Date
2013
MeSH
Adult ; Bone Neoplasms/blood* ; Bone Neoplasms/mortality ; Bone Neoplasms/secondary ; Breast Neoplasms/blood* ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Carcinoembryonic Antigen/blood* ; Female ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/blood* ; Lung Neoplasms/mortality ; Lung Neoplasms/secondary ; Mucin-1/blood* ; Multivariate Analysis ; Neoplasm Recurrence, Local/blood* ; Prognosis ; Proportional Hazards Models ; Tumor Burden
Keywords
Adult ; Bone Neoplasms/blood* ; Bone Neoplasms/mortality ; Bone Neoplasms/secondary ; Breast Neoplasms/blood* ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Carcinoembryonic Antigen/blood* ; Female ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/blood* ; Lung Neoplasms/mortality ; Lung Neoplasms/secondary ; Mucin-1/blood* ; Multivariate Analysis ; Neoplasm Recurrence, Local/blood* ; Prognosis ; Proportional Hazards Models ; Tumor Burden
Abstract
To investigate the prognostic value of tumor markers, cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA) levels at diagnosis of systemic recurrence. After primary treatments of locoregional breast cancers, serum CA 15-3 and/or CEA concentrations were regularly measured, and systemic recurrences were identified in 351 patients between January 1999 and December 2009. The association between tumor marker levels at systemic recurrence and survival were investigated by univariate and multivariate analyses. Elevated CA 15-3 and CEA levels were identified in 194 of 349 (55.6 %) and 111 of 308 (36.0 %) patients, respectively, at diagnosis of systemic recurrence. Elevated levels of CA 15-3 and CEA were correlated with visceral or multiple recurrences and elevated preoperative levels. Elevation of CA 15-3 was more prominent in younger patients and in primary node-positive tumors, while CEA was elevated in older patients at diagnosis and in estrogen receptor (ER)-positive tumors. Elevated tumor markers as well as ER negativity, short disease-free interval, and advanced stage at initial diagnosis showed independent prognostic significance on multivariate analysis. Among 306 patients for whom levels of both tumor markers at recurrence were available, 106 patients without elevation of either marker showed significantly better overall survival than those with elevated levels of either one or both markers, and the significance persisted in multivariate analysis. Elevated serum CA 15-3 and CEA levels at recurrence suggest increased tumor burden and may be prognostic for survival for metastatic breast cancer patients
Full Text
http://dx.doi.org/10.1007/s10549-013-2695-7
DOI
10.1007/s10549-013-2695-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Il(김승일)
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Park, Ji Min(박지민)
Lee, Jun Sang(이준상) ORCID logo https://orcid.org/0000-0002-4054-6900
Cho, Jung Hoon(조정훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/88958
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